Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis‐associated cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Communications"
DOI: 10.1002/cac2.12184
Abstract: Mitochondria are key regulators in cell proliferation and apoptosis. Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis. This study aimed to investigate whether mitochondrial transcription factor A (TFAM), a key regulator of… read more here.
Keywords: transcription; initiation progression; mitochondrial transcription; transcription factor ... See more keywords
Fatty Acid Mediators in the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-43093-1_8
Abstract: Patients with cancer frequently overexpress inflammatory cytokines with an associated neutrophilia both of which may be downregulated by diets with high omega-3 polyunsaturated fatty acids (ω-3 PUFA). The anti-inflammatory activity of dietary ω-3 PUFA has… read more here.
Keywords: fatty acid; tumor initiation; initiation progression; acid mediators ... See more keywords
Breaking through to the Other Side: Microenvironment Contributions to DCIS Initiation and Progression
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-018-9409-z
Abstract: Refinements in early detection, surgical and radiation therapy, and hormone receptor-targeted treatments have improved the survival rates for breast cancer patients. However, the ability to reliably identify which non-invasive lesions and localized tumors have the… read more here.
Keywords: side microenvironment; carcinoma; breaking side; initiation progression ... See more keywords
Oncogene-induced regulation of microRNA expression: Implications for cancer initiation, progression and therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.02.029
Abstract: A plethora of tumours have characteristic oncogenic mutations which are the main causes of malignant transformation, exerting their effects through multiple signalling pathways. Downstream of such pathways, microRNAs are small non-coding RNAs that negatively regulate… read more here.
Keywords: cancer; expression; initiation progression; oncogene induced ... See more keywords
A spatially explicit crop planting initiation and progression model for the conterminous United States
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Agronomy"
DOI: 10.1016/j.eja.2017.08.004
Abstract: Abstract The ability to accurately estimate crop planting date and planting progression has major implications in crop management, crop model applications, and in developing adaptation strategies for future climate change. The objectives of this study… read more here.
Keywords: initiation progression; model; planting initiation; progression ... See more keywords
Reprogramming progeria fibroblasts re‐establishes a normal epigenetic landscape
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12621
Abstract: Ideally, disease modeling using patient‐derived induced pluripotent stem cells (iPSCs) enables analysis of disease initiation and progression. This requires any pathological features of the patient cells used for reprogramming to be eliminated during iPSC generation.… read more here.
Keywords: reprogramming progeria; initiation progression; epigenetic landscape; landscape ... See more keywords
Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add8977
Abstract: Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-characterized pathological stages of initiation and progression. However, high-resolution knowledge of the transcriptional programs underlying each stage of CESC is lacking, and important questions… read more here.
Keywords: cell; initiation progression; progression; squamous cell ... See more keywords
TET2-Dependent Hydroxymethylome Plasticity Reduces Melanoma Initiation and Progression.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-1214
Abstract: Although numerous epigenetic aberrancies accumulate in melanoma, their contribution to initiation and progression remain unclear. The epigenetic mark 5-hydroxymethylcytosine (5hmC), generated through TET-mediated DNA modification, is now referred to as the sixth base of DNA… read more here.
Keywords: tet2; initiation; progression; initiation progression ... See more keywords
Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-3607
Abstract: Truncated ASPP2 cooperates with E-cadherin and PTEN loss to drive breast cancer initiation and progression via two distinct mechanisms. ASPP2-induced actomyosin relaxation drives tumor initiation, while ASPP2-mediated YAP activation enhances tumor progression. Invasive lobular carcinoma… read more here.
Keywords: initiation; progression; initiation progression; loss ... See more keywords
Fasting Inhibits the Initiation and Progression of B-ALL and T-ALL.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2016-238
Abstract: Fasting upregulates the leptin receptor (LEPR) to block development of B-ALL and T-ALL, but not AML. read more here.
Keywords: initiation progression; inhibits initiation; fasting inhibits;
Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer"
DOI: 10.1186/s12943-018-0926-6
Abstract: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high morbidity, relapse and mortality rates. Multipotent mesenchymal stromal cells (MSCs) can be recruited to and become integral components of the HCC… read more here.
Keywords: hepatocellular carcinoma; mesenchymal stromal; stromal cells; initiation progression ... See more keywords