Therapeutic efficacy of an injectable formulation of purinostat mesylate in SU-DHL-6 tumour model
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DOI: 10.1080/07853890.2022.2045347
Abstract: Abstract Background: Previous studies have proven that Purinostat Mesylate (PM) is a new HDAC inhibitor and exhibits significant antitumor efficacy. However, the clinical application of PM was greatly limited by its poor solubility in water… read more here.
Keywords: purinostat mesylate; solubility; spectroscopy; efficacy ... See more keywords
Long-acting injectable formulation technologies: challenges and opportunities for the delivery of fragile molecules
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DOI: 10.1080/17425247.2022.2105318
Abstract: ABSTRACT Introduction The development of long-acting injectables (LAIs) for protein and peptide therapeutics has been a key challenge over the last 20 years. If these molecules offer advantages due to their high specificity and selectivity,… read more here.
Keywords: formulation technologies; technologies challenges; acting injectable; long acting ... See more keywords
Pharmacokinetics and pharmacodynamics of the injectable formulation of methadone hydrochloride and methadone in lipid nanocarriers administered orally to horses
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DOI: 10.1111/jvp.12393
Abstract: We investigated the thermal, electrical and mechanical antinociceptive and physiological effects (heart rate, respiratory rate, arterial blood pressure, head height and abdominal auscultation score), and pharmacokinetics, of 0.5 mg/kg of the injectable formulation (ORAL) or nanoparticulated… read more here.
Keywords: administered orally; injectable formulation; methadone; orally horses ... See more keywords