Protosappanin‐A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT‐mTOR signaling
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DOI: 10.1002/cbin.11218
Abstract: Protosappanin‐A (PrA) and oleanolic acid (OA), which are important effective ingredients isolated from Caesalpinia sappan L., exhibit therapeutic potential in multiple diseases. This study focused on exploring the mechanisms of PrA and OA function in… read more here.
Keywords: akt; injured podocytes; oleanolic acid; akt mtor ... See more keywords
Injured Podocytes Are Sensitized to Angiotensin II-Induced Calcium Signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2019020109
Abstract: BACKGROUND Inhibition of angiotensin II (AngII) signaling, a therapeutic mainstay of glomerular kidney diseases, is thought to act primarily through regulating glomerular blood flow and reducing filtration pressure. Although extravascular actions of AngII have been… read more here.
Keywords: induced calcium; responsiveness angii; calcium; injured podocytes ... See more keywords