Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03062-8
Abstract: Antisense oligonucleotides (ASOs) are a promising therapeutic modality. However, failure to predict acute kidney injury induced by SPC5001 ASO observed in a clinical trial suggests the need for additional preclinical models to complement the preceding… read more here.
Keywords: kidney injury; proximal tubule; injury biomarkers; injury ... See more keywords
Evaluation of acute kidney injury in dogs with complicated or uncomplicated Babesia rossi infection.
Sign Up to like & getrecommendations! Published in 2020 at "Ticks and tick-borne diseases"
DOI: 10.1016/j.ttbdis.2020.101406
Abstract: Dogs with babesiosis can present with multiple complications, including acute kidney injury (AKI). The objective of this study was to characterize AKI in dogs with babesiosis caused by Babesia rossi at presentation and after treatment.… read more here.
Keywords: kidney injury; injury biomarkers; dogs complicated; injury ... See more keywords
SERS detection of radiation injury biomarkers in mouse serum
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DOI: 10.1039/c7ra12238a
Abstract: In a large-scale radiological catastrophe, it is expected that hundreds and thousands of people could be exposed to radiation. A rapid method is required for triage of casualties to determine proper medical treatment. In this… read more here.
Keywords: detection radiation; radiation injury; biomarkers mouse; sers detection ... See more keywords
The role of kidney injury biomarkers in COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2107544
Abstract: Abstract The coronavirus disease-2019 (COVID-19) outbreak has been declared a global pandemic. COVID-19-associated acute kidney injury (COVID-19 AKI) is related to a high mortality rate and serves as an independent risk factor for hospital death… read more here.
Keywords: kidney; kidney injury; covid; role kidney ... See more keywords
Screening of radiation gastrointestinal injury biomarkers in rat plasma by high-coverage targeted lipidomics
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DOI: 10.1080/1354750x.2022.2056920
Abstract: Abstract Introduction In the event of radiological accidents and cancer radiotherapies in the clinic, the gastrointestinal (GI) system is vulnerable to ionizing radiation and shows GI injury. Accessible biomarkers may provide means to predict, evaluate,… read more here.
Keywords: biomarkers rat; rat plasma; radiation; injury ... See more keywords
Impact of Vancomycin Loading Doses and Dose Escalation on Glomerular Function and Kidney Injury Biomarkers in a Translational Rat Model
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DOI: 10.1128/aac.01276-22
Abstract: Vancomycin-induced kidney injury is common, and outcomes in humans are well predicted by animal models. This study employed our translational rat model to investigate temporal changes in the glomerular filtration rate (GFR) and correlations with… read more here.
Keywords: kidney injury; rat model; translational rat; injury ... See more keywords
Circulating Brain Injury Biomarkers: A Novel Method for Quantification of the Impact on the Brain After Tumor Surgery.
Sign Up to like & getrecommendations! Published in 2023 at "Neurosurgery"
DOI: 10.1227/neu.0000000000002510
Abstract: BACKGROUND Clinical methods to quantify brain injury related to neurosurgery are scarce. Circulating brain injury biomarkers have recently gained increased interest as new ultrasensitive measurement techniques have enabled quantification of brain injury through blood sampling.… read more here.
Keywords: surgery; brain; circulating brain; brain injury ... See more keywords
Kidney Injury Biomarkers in Leptospirosis
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DOI: 10.1590/0037-8682-0260-2022
Abstract: ABSTRACT Leptospirosis is a zoonotic infection with a global distribution, though it has a greater impact on marginalized rural agricultural and urban communities in developing countries. Kidney injury, which can lead to severe and lethal… read more here.
Keywords: kidney; kidney injury; injury biomarkers; biomarkers leptospirosis ... See more keywords
Drug-Induced Liver Injury: Biomarkers, Requirements, Candidates, and Validation
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DOI: 10.3389/fphar.2019.01482
Abstract: The hepatotoxicity of drugs is the main cause of drug withdrawal from the pharmaceutical market and interruption of the development of new molecules. Biomarkers are useful in several situations. In case of suspected drug-induced liver… read more here.
Keywords: liver injury; drug induced; drug; induced liver ... See more keywords
Effects of early adjunctive pharmacotherapy on serum levels of brain injury biomarkers in patients with traumatic brain injury: a systematic review of randomized controlled studies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1185277
Abstract: Objectives: Traumatic brain injury (TBI) is one of the top causes of morbidity and mortality worldwide. The review aimed to discuss and summarize the current evidence on the effectiveness of adjuvant neuroprotective treatments in terms… read more here.
Keywords: traumatic brain; randomized controlled; brain injury; injury ... See more keywords
Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10090823
Abstract: Simple Summary Cardiac surgery associated acute kidney injury is a common complication of cardiac surgeries that worsens postoperative outcomes and the patient’s prognosis. One of the main problems concerning this complication is its early diagnostics.… read more here.
Keywords: kidney injury; csa aki; acute kidney; injury biomarkers ... See more keywords