Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats
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DOI: 10.1080/19336950.2021.2023383
Abstract: ABSTRACT The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target. However,… read more here.
Keywords: small molecule; chronic constriction; constriction injury; injury ... See more keywords