High-throughput metabolomics discovers metabolite biomarkers and insights the protective mechanism of schisandrin B on myocardial injury rats.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000875
Abstract: Schisandrin B has been proved to possess anti-inflammatory and anti-endoplasmic effects, could improve cardiac function, inhibit apoptosis, and reduce inflammation after ischemic injury. However, the detailed metabolic mechanism and potential pathways of Schisandrin B effects… read more here.
Keywords: injury rats; mechanism schisandrin; myocardial injury; injury ... See more keywords
Neuroglobin protects against cerebral ischemia/reperfusion injury in rats by suppressing mitochondrial dysfunction and endoplasmic reticulum stress-mediated neuronal apoptosis through synaptotagmin-1.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23815
Abstract: Cerebral ischemia/reperfusion (I/R) injury remains a grievous health threat, and herein effective therapy is urgently needed. This study explored the protection of neuroglobin (Ngb) in rats with cerebral I/R injury. The focal cerebral I/R rat… read more here.
Keywords: endoplasmic reticulum; apoptosis; reticulum stress; injury rats ... See more keywords
Oleuropein Protects Against Cerebral Ischemia Injury in Rats: Molecular Docking, Biochemical and Histological Findings.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03351-9
Abstract: This study was designed to evaluate the underlying protective mechanisms of oleuropein involved in alleviating brain damage in a rat model of ischemic stroke. Male Wistar rats were divided into four groups; Control, stroke (MCAO),… read more here.
Keywords: injury rats; ischemia injury; protects cerebral; cerebral ischemia ... See more keywords
Changes in inflammatory factors and protein expression in sulfur mustard (1LD50)‐induced acute pulmonary injury in rats
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.06.025
Abstract: HighlightsAnimal model of SM was established by equal toxicity dose (1LD50)‐induced acute pulmonary injury in rats using two methods.Serum inflammatory factors and proteins in alveolar septa of the intraperitoneal SM group were increased.The effects of… read more here.
Keywords: injury rats; 1ld50 induced; pulmonary injury; inflammatory factors ... See more keywords
Betulin alleviates cisplatin-induced hepatic injury in rats: Targeting apoptosis and Nek7-independent NLRP3 inflammasome pathways.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107925
Abstract: Cisplatin is a chemotherapeutic agent that induces multiorgan toxicity side effect due to induction of inflammation, apoptosis and disruption of intracellular antioxidant pathways. Betulin is a natural triterpenoid that has been shown to counteract cisplatin-induced… read more here.
Keywords: injury rats; cisplatin; effect; cisplatin induced ... See more keywords
Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 1: Metabolic profiles from the liver-centric perspective.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.03.044
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Yin-Chen-Hao Tang (YCHT), derived from "Treatise on Febrile Diseases" in ancient China, has been a very popular hepatoprotective three-herb formula in China and Japan, although its chemical base remains unclear. AIM OF THIS… read more here.
Keywords: chemical base; injury rats; plasma; ycht ... See more keywords
Dishevelled-1 regulated apoptosis through NF-κB in cerebral ischemia/reperfusion injury in rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134862
Abstract: Dishevelled-1(DVL-1) has been reported associated with the regulation of cell polarity and neuronal function. However, the effect of DVL-1 in cerebral ischemia-reperfusion injury of rats remains poorly understood. In this study, we give evidence that… read more here.
Keywords: injury rats; apoptosis; dvl; cerebral ischemia ... See more keywords
Allicin Attenuates Myocardial Ischemia Reperfusion Injury in Rats by Inhibition of Inflammation and Oxidative Stress.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.04.039
Abstract: OBJECTIVE To explore the protective effect and underlying mechanism of allicin (ALC) on myocardial ischemia reperfusion (MI/R) injury in rats. METHODS The model of MI/R injury in rats was induced by ligating the left anterior… read more here.
Keywords: injury rats; myocardial ischemia; expression; ischemia reperfusion ... See more keywords
Naloxone attenuates ischemic brain injury in rats through suppressing the NIK/IKKα/NF-κB and neuronal apoptotic pathways
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0053-3
Abstract: Although naloxone has been documented to exert neuroprotection in animal model of cerebral ischemia, the mechanism is not well understood. In this present study we investigated whether naloxone affected the mitochondrial apoptotic pathway in ischemic… read more here.
Keywords: injury rats; nik ikk; brain; ischemic brain ... See more keywords
The Possible Protective Effects of Ondansetron and Tropisetron on Optic Nerve Crush Injury in Rats
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DOI: 10.1055/a-1969-4600
Abstract: Abstract Background This study aimed to evaluate the potential neuroprotective effect of cyclosporine – a calcineurin inhibitor–, ondansetron, and tropisetron-5-hydroxytryptamine (serotonin) 3 receptor (5-HT3R) antagonists–, on optic nerve crush (ONC) injury in rats. Moreover, underlying… read more here.
Keywords: injury rats; tropisetron; calcineurin; ondansetron tropisetron ... See more keywords
Non‐neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.16005
Abstract: The pro‐algesic transient receptor potential ankyrin 1 (TRPA1) channel, expressed by a subpopulation of primary sensory neurons, has been implicated in various pain models in mice. However, evidence in rats indicates that TRPA1 conveys nociceptive… read more here.
Keywords: inflammation; injury rats; nerve; mechanical allodynia ... See more keywords