Senescence promotes in vivo reprogramming through p16INK 4a and IL‐6
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DOI: 10.1111/acel.12711
Abstract: Cellular senescence is a damage response aimed to orchestrate tissue repair. We have recently reported that cellular senescence, through the paracrine release of interleukin‐6 (IL6) and other soluble factors, strongly favors cellular reprogramming by Oct4,… read more here.
Keywords: vivo reprogramming; senescence promotes; il6; senescence ... See more keywords
Constitutive Activation of Ras and Inactivation of Ink4a/Arf Allele Induce a Fully Penetrant B-Cell Acute Lymphoblastic Leukemia Phenotype in Mice
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DOI: 10.1182/blood.v130.suppl_1.1222.1222
Abstract: Abstract Despite recent advances in treatment, precursor-B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging clinical entity. Recent genome-wide studies have uncovered frequent genetic alterations involving activating RAS pathway mutations and loss of the INK4A/ARF locus… read more here.
Keywords: ink4a arfl; cd19cre krasg12d; ink4a; ink4a arf ... See more keywords
Genetic Alterations in the INK4a/ARF Locus: Effects on Melanoma Development and Progression
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DOI: 10.3390/biom10101447
Abstract: Genetic alterations in the INK4a/ARF (or CDKN2A) locus have been reported in many cancer types, including melanoma; head and neck squamous cell carcinomas; lung, breast, and pancreatic cancers. In melanoma, loss of function CDKN2A alterations… read more here.
Keywords: alterations ink4a; cdkn2a; genetic alterations; ink4a arf ... See more keywords