Constitutive Activation of Ras and Inactivation of Ink4a/Arf Allele Induce a Fully Penetrant B-Cell Acute Lymphoblastic Leukemia Phenotype in Mice
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DOI: 10.1182/blood.v130.suppl_1.1222.1222
Abstract: Abstract Despite recent advances in treatment, precursor-B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging clinical entity. Recent genome-wide studies have uncovered frequent genetic alterations involving activating RAS pathway mutations and loss of the INK4A/ARF locus… read more here.
Keywords: ink4a arfl; cd19cre krasg12d; ink4a; ink4a arf ... See more keywords