mTORC2 regulates multiple aspects of NKT‐cell development and function
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646343
Abstract: Invariant NKT (iNKT) cells bridge innate and adaptive immunity by rapidly secreting cytokines and lysing targets following TCR recognition of lipid antigens. Based on their ability to secrete IFN‐γ, IL‐4 and IL‐17A, iNKT‐cells are classified… read more here.
Keywords: inkt; cell development; inkt cell; function ... See more keywords
Ex Vivo Expansion of Th2-Polarizing Immunotherapeutic iNKT Cells from Human Peripheral Blood.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1775-5_13
Abstract: iNKT cells, classified as innate lymphocytes with invariant TCRs, have been highlighted as a putative, "off-the-shelf" cellular immunotherapeutic strategy for the treatment of malignant and nonmalignant diseases. However, their paucity in human blood limits their… read more here.
Keywords: vivo expansion; inkt; expansion th2; blood ... See more keywords
Identifying, Isolation, and Functional Use of Human Liver iNKT Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1775-5_6
Abstract: It is widely accepted that iNKT cells are abundant in the liver and play a role in various liver disorders. In here, we describe an optimized protocol in identifying and isolating invariant natural killer T… read more here.
Keywords: functional use; inkt; liver; identifying isolation ... See more keywords
iNKT cells are increased in children with severe therapy-resistant asthma.
Sign Up to like & getrecommendations! Published in 2018 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2017.05.009
Abstract: BACKGROUND Invariant natural killer T (iNKT) cells play complex functions in the immune system, releasing both Th1 and Th2 cytokines. The role of iNKT cells in human asthma is still controversial and never described in… read more here.
Keywords: inkt; severe therapy; therapy resistant; inkt cells ... See more keywords
Invariant Natural Killer T cells resilience to paradoxical sleep deprivation-associated stress
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.08.018
Abstract: Although several studies demonstrate that stressful situations, such as sleep disturbances, negatively impact the innate and adaptive arms of the immune system, their influence on invariant Natural Killer T (iNKT) cells remains unclear. iNKT cells… read more here.
Keywords: sleep deprivation; inkt; invariant natural; natural killer ... See more keywords
iNKT cells and hematopoietic stem cell transplantation: Two-phase activation of iNKT cells may improve outcome.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.05.011
Abstract: Invariant natural killer T cells (iNKT) produce large amounts of different cytokines which can influence differentiation, polarization and activation of immune cells, particularly NK and T cells. iNKT have been shown to suppress GvHD and… read more here.
Keywords: inkt; cell transplantation; stem cell; hematopoietic stem ... See more keywords
Unaltered influenza disease outcomes in swine prophylactically treated with α-galactosylceramide.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2020.103843
Abstract: Influenza A viruses (IAV) are a major cause of respiratory diseases in pigs. Invariant natural killer T (iNKT) cells are an innate-like T cell subset that contribute significantly to IAV resistance in mice. In the… read more here.
Keywords: inkt; unaltered influenza; infection; influenza disease ... See more keywords
Peptide-free Synthetic Nicotine Vaccine Candidates with α-Galactosylceramide as Adjuvant.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b01095
Abstract: Peptides are generally needed as T-helper epitopes in nicotine vaccines to induce effective antibody responses, but the highly polymorphic property of major histocompatibility complex (MHC) molecules may limit opportunities of B cell to receive CD4+… read more here.
Keywords: nicotine; synthetic nicotine; inkt; nicotine vaccine ... See more keywords
A New iNKT-Cell Agonist-Adjuvanted SARS-CoV-2 Subunit Vaccine Elicits Robust Neutralizing Antibody Responses.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00296
Abstract: Adjuvants are essential components of vaccines. Invariant natural killer T (iNKT) cells are a distinct subset of T cells that function to bridge the innate and adaptive immunities and are capable of mediating strong and… read more here.
Keywords: inkt; cell agonist; new inkt; inkt cell ... See more keywords
Leptin receptor antagonism of iNKT cell function: a novel strategy to combat multiple myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.146
Abstract: A hallmark of bone marrow changes with aging is the increase in adipocyte composition, but how this impacts development of multiple myeloma (MM) is unknown. Here, we report the role of the adipokine leptin as… read more here.
Keywords: inkt; leptin receptor; cell function; multiple myeloma ... See more keywords
Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal immunology"
DOI: 10.1038/mi.2016.34
Abstract: Invariant natural killer T (iNKT) cells are innate-like T cells that respond to lipid antigens presented by CD1d. These immunoregulatory cells have the capacity for rapid cytokine release after antigen recognition and are essential for… read more here.
Keywords: hiv infection; cell; inkt; inkt cell ... See more keywords