mTORC2 regulates multiple aspects of NKT‐cell development and function
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646343
Abstract: Invariant NKT (iNKT) cells bridge innate and adaptive immunity by rapidly secreting cytokines and lysing targets following TCR recognition of lipid antigens. Based on their ability to secrete IFN‐γ, IL‐4 and IL‐17A, iNKT‐cells are classified… read more here.
Keywords: inkt; cell development; inkt cell; function ... See more keywords
The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.065
Abstract: The development of CD1d-restricted invariant natural killer T (iNKT) cells, a population that is critical for both innate and adaptive immunity, is regulated by multiple transcription factors, but the molecular mechanisms underlying how the transcriptional… read more here.
Keywords: gcn5; acetylation; cell development; inkt cell ... See more keywords
Feasibility of iNKT cell and PD-1+CD8+ T cell-based immunotherapy in patients with lung adenocarcinoma: Preliminary results of a phase I/II clinical trial.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical immunology"
DOI: 10.1016/j.clim.2022.108992
Abstract: We performed a single-arm exploratory clinical trial that is ongoing and registered at ClinicalTrials.gov (NCT03093688). Patients were infused with autologous iNKT cells, PD-1 + CD8+ T cells, and dendritic cells every 3-5 weeks, which was considered 1 cycle. The… read more here.
Keywords: response; clinical trial; preliminary results; inkt cell ... See more keywords
A New iNKT-Cell Agonist-Adjuvanted SARS-CoV-2 Subunit Vaccine Elicits Robust Neutralizing Antibody Responses.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00296
Abstract: Adjuvants are essential components of vaccines. Invariant natural killer T (iNKT) cells are a distinct subset of T cells that function to bridge the innate and adaptive immunities and are capable of mediating strong and… read more here.
Keywords: inkt; cell agonist; new inkt; inkt cell ... See more keywords
Leptin receptor antagonism of iNKT cell function: a novel strategy to combat multiple myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.146
Abstract: A hallmark of bone marrow changes with aging is the increase in adipocyte composition, but how this impacts development of multiple myeloma (MM) is unknown. Here, we report the role of the adipokine leptin as… read more here.
Keywords: inkt; leptin receptor; cell function; multiple myeloma ... See more keywords
Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal immunology"
DOI: 10.1038/mi.2016.34
Abstract: Invariant natural killer T (iNKT) cells are innate-like T cells that respond to lipid antigens presented by CD1d. These immunoregulatory cells have the capacity for rapid cytokine release after antigen recognition and are essential for… read more here.
Keywords: hiv infection; cell; inkt; inkt cell ... See more keywords
The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells
Sign Up to like & getrecommendations! Published in 2017 at "Nature immunology"
DOI: 10.1038/ni.3644
Abstract: Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development. Here we found that the… read more here.
Keywords: demethylase; lineage; inkt; invariant natural ... See more keywords
SLAM-ing the brakes on iNKT cell selection
Sign Up to like & getrecommendations! Published in 2019 at "Nature Immunology"
DOI: 10.1038/s41590-019-0355-8
Abstract: Members of the SLAM family of receptors promote the progression of invariant natural killer T cells through the thymic maturation process and facilitate proper host responses to exogenous lipid antigen through the recruitment and activity… read more here.
Keywords: slam ing; ing brakes; immunology; inkt cell ... See more keywords
Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28396-9
Abstract: Graphene oxide (GO) modulates the functions of antigen-presenting cells including dendritic cells (DCs). Although carbon nanotubes affect expression of the MHC class I-like CD1d molecule, whether GO can influence immune responses of CD1d-dependent invariant natural… read more here.
Keywords: graphene oxide; production; inkt; inkt cell ... See more keywords
The autophagy machinery restrains iNKT cell activation through CD1D1 internalization
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1297907
Abstract: ABSTRACT Invariant natural killer T (iNKT) cells are innate T cells with powerful immune regulatory functions that recognize glycolipid antigens presented by the CD1D protein. While iNKT cell-activating glycolipids are currently being explored for their… read more here.
Keywords: cell activation; cd1d1; cell; inkt cell ... See more keywords
iNKT cell defects in HHV-8-associated MCD.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-11-751875
Abstract: In this issue of Blood , [Sbihi et al][1] provide the first evidence of invariant natural killer T (iNKT) cell abnormalities in patients with human herpesvirus 8 (HHV-8) –associated multicentric Castleman disease (MCD).[1][2] ![Figure][3] Model… read more here.
Keywords: associated mcd; cell defects; hhv associated; inkt cell ... See more keywords