Styk1 is specifically expressed in NK1.1+ lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201848033
Abstract: Innate T cells, NK cells, and innate‐like lymphocytes (ILCs) share transcriptional signatures that translate into overlapping developmental and functional programs. A prominent example for genes that are highly expressed in NK cells but not in… read more here.
Keywords: styk1 specifically; specifically expressed; styk1; function ... See more keywords
Ex Vivo Expansion of Th2-Polarizing Immunotherapeutic iNKT Cells from Human Peripheral Blood.
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DOI: 10.1007/978-1-0716-1775-5_13
Abstract: iNKT cells, classified as innate lymphocytes with invariant TCRs, have been highlighted as a putative, "off-the-shelf" cellular immunotherapeutic strategy for the treatment of malignant and nonmalignant diseases. However, their paucity in human blood limits their… read more here.
Keywords: vivo expansion; inkt; expansion th2; blood ... See more keywords
Identifying, Isolation, and Functional Use of Human Liver iNKT Cells.
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DOI: 10.1007/978-1-0716-1775-5_6
Abstract: It is widely accepted that iNKT cells are abundant in the liver and play a role in various liver disorders. In here, we describe an optimized protocol in identifying and isolating invariant natural killer T… read more here.
Keywords: functional use; inkt; liver; identifying isolation ... See more keywords
The role of invariant T cells in inflammation of the skin and airways
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-019-00740-9
Abstract: Invariant and semi-invariant T cells are emerging as important regulators of host environment interactions at barrier tissues such as the airway and skin. In contrast to conventional T cells, invariant natural killer T (iNKT) cells… read more here.
Keywords: skin airways; mait cells; inkt cells; inflammation ... See more keywords
iNKT cells are increased in children with severe therapy-resistant asthma.
Sign Up to like & getrecommendations! Published in 2018 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2017.05.009
Abstract: BACKGROUND Invariant natural killer T (iNKT) cells play complex functions in the immune system, releasing both Th1 and Th2 cytokines. The role of iNKT cells in human asthma is still controversial and never described in… read more here.
Keywords: inkt; severe therapy; therapy resistant; inkt cells ... See more keywords
Invariant Natural Killer T cells resilience to paradoxical sleep deprivation-associated stress
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DOI: 10.1016/j.bbi.2020.08.018
Abstract: Although several studies demonstrate that stressful situations, such as sleep disturbances, negatively impact the innate and adaptive arms of the immune system, their influence on invariant Natural Killer T (iNKT) cells remains unclear. iNKT cells… read more here.
Keywords: sleep deprivation; inkt; invariant natural; natural killer ... See more keywords
Retinoic acid induction of CD1d expression primes chronic lymphocytic leukemia B cells for killing by CD8+ invariant natural killer T cells.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.08.002
Abstract: Invariant natural killer T (iNKT) cells are cytotoxic T cells that respond to glycolipid antigens presented by CD1d. Therapeutic activation of iNKT cells with α-galactosylceramide (α-GalCer) can prevent and reverse tumor growth in mice and… read more here.
Keywords: cd1d expression; invariant natural; inkt cells; natural killer ... See more keywords
iNKT cells and hematopoietic stem cell transplantation: Two-phase activation of iNKT cells may improve outcome.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.05.011
Abstract: Invariant natural killer T cells (iNKT) produce large amounts of different cytokines which can influence differentiation, polarization and activation of immune cells, particularly NK and T cells. iNKT have been shown to suppress GvHD and… read more here.
Keywords: inkt; cell transplantation; stem cell; hematopoietic stem ... See more keywords
Unaltered influenza disease outcomes in swine prophylactically treated with α-galactosylceramide.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2020.103843
Abstract: Influenza A viruses (IAV) are a major cause of respiratory diseases in pigs. Invariant natural killer T (iNKT) cells are an innate-like T cell subset that contribute significantly to IAV resistance in mice. In the… read more here.
Keywords: inkt; unaltered influenza; infection; influenza disease ... See more keywords
iNKT cells need UTX-tra demethylation
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DOI: 10.1038/ni.3663
Abstract: The epigenetic regulation of gene expression by the histone demethylase UTX is central to the development of invariant natural killer cells. read more here.
Keywords: utx tra; cells need; tra demethylation; inkt cells ... See more keywords
Systemic lupus erythematosus: iNKT cells guard the heart against disease
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2016.216
Abstract: Invariant natural killer T (iNKT) cells might have an atheroprotective role in patients with systemic lupus erythematosus (SLE) who have asymptomatic atherosclerotic plaques, according to new research. “For the first time, we describe a link… read more here.
Keywords: systemic lupus; lupus erythematosus; disease; inkt cells ... See more keywords