First-in-Human Phase I Study of a CD16A Bispecific Innate Cell Engager, AFM24, Targeting EGFR-Expressing Solid Tumors
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-24-1991
Abstract: Abstract Purpose: Innate immune cell–based therapies have shown promising antitumor activity against solid and hematologic malignancies. AFM24, a bispecific innate cell engager, binds CD16A on NK cells/macrophages and EGFR on tumor cells, redirecting antitumor activity… read more here.
Keywords: solid tumors; innate cell; bispecific innate; innate ... See more keywords
Single-cell transcriptome mapping identifies a local, innate B cell population driving chronic rejection after lung transplantation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.156648
Abstract: Bronchiolitis obliterans syndrome (BOS) is the main reason for poor outcomes after lung transplantation (LTx). We and others have recently identified B cells as major contributors to BOS after LTx. The extent of B cell… read more here.
Keywords: lung transplantation; cell; innate cell; chronic rejection ... See more keywords
Vitamin A deficiency and vitamin A supplementation affect innate and T cell immune responses to rotavirus A infection in a conventional sow model
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1188757
Abstract: Rotavirus A (RVA) causes ~200,000 diarrheal deaths annually in children read more here.
Keywords: rva; supplementation; vad; immune responses ... See more keywords
Cryopreservation of Natural Killer Cells Pre-Complexed with Innate Cell Engagers
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DOI: 10.3390/antib11010012
Abstract: Innate cell engager (ICE®) constructs are bispecific tetravalent antibodies targeting specific tumor antigens and simultaneously engaging natural killer (NK) cell and macrophage receptors for the destruction of tumor cells. Pre-complexing of ICE® constructs with adoptive… read more here.
Keywords: cells pre; cell; ice; natural killer ... See more keywords