Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus.
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DOI: 10.1002/advs.202207249
Abstract: Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of… read more here.
Keywords: immune responses; pathogenic coronavirus; antiviral nanobiologic; innate immune ... See more keywords
Synthetic Cancer‐Targeting Innate Immune Stimulators Give Insights into Avidity Effects
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DOI: 10.1002/cbic.201700522
Abstract: Multispecific and multivalent antibodies are seen as promising cancer therapeutics, and numerous antibody fragments and derivatives have been developed to exploit avidity effects that result in increased selectivity. Most of these multispecific and multivalent antibody… read more here.
Keywords: avidity; immune stimulators; cancer; innate immune ... See more keywords
Altered innate immune profile in blood of systemic mastocytosis patients
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DOI: 10.1002/clt2.12167
Abstract: Abstract Background Mast cells (MC) from systemic mastocytosis (SM) patients release MC mediators that lead to an altered microenvironment with potential consequences on innate immune cells, such as monocytes and dendritic cells (DC). Here we… read more here.
Keywords: systemic mastocytosis; innate immune; blood; blood monocytes ... See more keywords
A hidden cost of migration? Innate immune function versus antioxidant defense
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DOI: 10.1002/ece3.3756
Abstract: Abstract Migration is energetically demanding and physiologically challenging. Migrating birds, for example, need to boost their antioxidant defenses to defeat the pro‐oxidants produced during high energetic activity. The enhanced antioxidant defense possibly withdraws limited resources… read more here.
Keywords: defense; migration; antioxidant defense; innate immune ... See more keywords
Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells and microbiota.
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DOI: 10.1002/eji.202149401
Abstract: The intestinal mucosal barrier is critical for the absorption of nutrients and the health of both humans and animals. Recent publications from clinical and experimental studies have shown the importanceof the nutrients-bacteria-host interaction for the… read more here.
Keywords: immune; tryptophan innate; host; intestinal homeostasis ... See more keywords
Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities
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DOI: 10.1002/eji.202149410
Abstract: Activation of the coagulation cascade is a critical, evolutionarily conserved mechanism that maintains hemostasis by rapidly forming blood clots in response to blood‐borne infections and damaged blood vessels. Coagulation is a key component of innate… read more here.
Keywords: signaling immunothrombosis; coagulation; immune signaling; immunothrombosis new ... See more keywords
COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions
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DOI: 10.1002/eji.202249827
Abstract: We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID‐19 induces a rapid, transient upregulation of myeloid‐derived suppressor cells (MDSCs) accompanied… read more here.
Keywords: mdscs prolongs; covid rapidly; rapidly increases; innate immune ... See more keywords
Type I interferon signaling deficiency results in dysregulated innate immune responses to SARS‐CoV‐2 in mice
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DOI: 10.1002/eji.202249913
Abstract: SARS‐CoV‐2 is a newly emerged coronavirus, causing the global pandemic of respiratory coronavirus disease (COVID‐19). The type I interferon (IFN) pathway is of particular importance for anti‐viral defense and recent studies identified that type I… read more here.
Keywords: ifn; innate immune; responses sars; type interferon ... See more keywords
ER stress and the inflammatory response in allergic contact dermatitis.
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DOI: 10.1002/eji.202249984
Abstract: Maintaining homeostasis is central to organismal health. Deviation is detected by a variety of sensors that react to alarm signals arising from injury, infection and other inflammatory triggers. One important element of this alarm system… read more here.
Keywords: system; innate immune; allergic contact; response ... See more keywords
Trained immunity from the perspective of Plasmodium Infection.
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DOI: 10.1002/eji.202250268
Abstract: The immune system of vertebrates includes innate immunity and adaptive immunity, and the network between them enables the host to fight against invasions of various pathogens. Recently, studies discovered that immune memory is one of… read more here.
Keywords: plasmodium; trained immunity; immunity; innate immune ... See more keywords
VEGF as a modulator of the innate immune response in glioblastoma
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DOI: 10.1002/glia.23234
Abstract: VEGF is an important factor in tumor vascularization and used as target for anti‐angiogenic treatment strategies in glioma. In this study, we demonstrate for the first time that VEGF is a modulator of the innate… read more here.
Keywords: microglia macrophages; innate immune; vegf; immune response ... See more keywords