Association of Obesity and Innate Immune Markers With Resistance to Biologic Therapy in Psoriasis.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2025.0288
Abstract: Importance Currently available biologics specifically target dermal adaptive immune molecules, such as interleukin (IL)-17 and IL-23, which are crucial in the pathogenesis of psoriasis. Despite their remarkably enhanced therapeutic effects compared with those of traditional… read more here.
Keywords: biologic therapy; treatment; dermatology; psoriasis ... See more keywords
A Genetically Engineered “Reinforced Concrete” Scaffold Regulates the N2 Neutrophil Innate Immune Cascade to Repair Bone Defects
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202304585
Abstract: The innate immune response is crucial to inflammation, but how neutrophils and macrophages act in bone repair and tissue engineering treatment strategies await clarification. In this study, it is found that N2 neutrophils release stronger… read more here.
Keywords: bone; genetically engineered; repair; innate immune ... See more keywords
Preventing Glioblastoma Relapse by Igniting Innate Immunity through Mitochondrial Stress in the Surgical Cavity.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202511351
Abstract: Innate immunity is crucial in orchestrating the brain immune response, however, glioblastoma multiforme (GBM) has evolved sophisticated mechanisms to evade innate immune surveillance, posing significant challenges for current immunotherapies. Here, a therapeutic strategy is reported… read more here.
Keywords: innate immunity; mitochondrial stress; stress; gbm ... See more keywords
Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202207249
Abstract: Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of… read more here.
Keywords: immune responses; pathogenic coronavirus; antiviral nanobiologic; innate immune ... See more keywords
Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308978
Abstract: Innate immune training involves myelopoiesis, dynamic gene modulation, and functional reprogramming of myeloid cells in response to secondary heterologous challenges. The present study evaluates whether systemic innate immune training can protect tissues from local injury.… read more here.
Keywords: training; lung injury; injury; immune training ... See more keywords
Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507146
Abstract: Innate immunity is the first line of defense against viral infections. Cyclic GMP‐AMP synthase (cGAS) senses abnormal cytosolic double‐stranded DNA (dsDNA) and triggers the production of interferon and proinflammatory cytokines to eliminate viruses, whereas three‐prime… read more here.
Keywords: cgas; trex1; gigaxonin; antiviral innate ... See more keywords
Synthetic Cancer‐Targeting Innate Immune Stimulators Give Insights into Avidity Effects
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201700522
Abstract: Multispecific and multivalent antibodies are seen as promising cancer therapeutics, and numerous antibody fragments and derivatives have been developed to exploit avidity effects that result in increased selectivity. Most of these multispecific and multivalent antibody… read more here.
Keywords: avidity; immune stimulators; cancer; innate immune ... See more keywords
Altered innate immune profile in blood of systemic mastocytosis patients
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12167
Abstract: Abstract Background Mast cells (MC) from systemic mastocytosis (SM) patients release MC mediators that lead to an altered microenvironment with potential consequences on innate immune cells, such as monocytes and dendritic cells (DC). Here we… read more here.
Keywords: systemic mastocytosis; innate immune; blood; blood monocytes ... See more keywords
A hidden cost of migration? Innate immune function versus antioxidant defense
Sign Up to like & getrecommendations! Published in 2018 at "Ecology and Evolution"
DOI: 10.1002/ece3.3756
Abstract: Abstract Migration is energetically demanding and physiologically challenging. Migrating birds, for example, need to boost their antioxidant defenses to defeat the pro‐oxidants produced during high energetic activity. The enhanced antioxidant defense possibly withdraws limited resources… read more here.
Keywords: defense; migration; antioxidant defense; innate immune ... See more keywords
Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells and microbiota.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202149401
Abstract: The intestinal mucosal barrier is critical for the absorption of nutrients and the health of both humans and animals. Recent publications from clinical and experimental studies have shown the importanceof the nutrients-bacteria-host interaction for the… read more here.
Keywords: immune; tryptophan innate; host; intestinal homeostasis ... See more keywords
Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149410
Abstract: Activation of the coagulation cascade is a critical, evolutionarily conserved mechanism that maintains hemostasis by rapidly forming blood clots in response to blood‐borne infections and damaged blood vessels. Coagulation is a key component of innate… read more here.
Keywords: signaling immunothrombosis; coagulation; immune signaling; immunothrombosis new ... See more keywords