Interactions between the microbiota and innate and innate‐like lymphocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ri0917-378r
Abstract: The microbiota, which consists of commensal bacteria, fungi, and viruses, limits the colonization of pathogens at barrier tissues and promotes immune homeostasis. The latter is accomplished through the induction and regulation of both innate and… read more here.
Keywords: innate; like lymphocytes; innate innate; type innate ... See more keywords
Checkpoint inhibition in the treatment of multiple myeloma: A way to boost innate-like T cell anti-tumor function?
Sign Up to like & getrecommendations! Published in 2018 at "Molecular immunology"
DOI: 10.1016/j.molimm.2018.08.019
Abstract: Multiple myeloma (MM) is a progressive monoclonal B cell malignancy, for which survival and progression largely relies on the crosstalk of tumor cells with the bone marrow (BM) microenvironment, inducing immune escape, angiogenesis, bone destruction… read more here.
Keywords: innate; multiple myeloma; checkpoint inhibition; anti tumor ... See more keywords
The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04076-0
Abstract: Vδ2+ T cells form the predominant human γδ T-cell population in peripheral blood and mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we show that the Vδ2+ compartment comprises both innate-like and adaptive subsets.… read more here.
Keywords: compartment comprises; like adaptive; human cell; adaptive subsets ... See more keywords
Acute inflammation alters lung lymphocytes and potentiates innate-like behavior in young mouse lung CD8 T cells, resembling lung CD8 T cells from old mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad060
Abstract: Inflammation plays a significant role in lung infection including that caused by Mycobacterium tuberculosis (M.tb), where both adaptive and innate lymphocytes can affect infection control. How inflammation affects infection is understood in a broad sense,… read more here.
Keywords: inflammation; lung cd8; lung; cd8 cells ... See more keywords
Immune memory characteristics of innate lymphoid cells
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Infectious Diseases"
DOI: 10.1097/qco.0000000000000540
Abstract: Purpose of review Immune memory is essential for host defense against invaders and it is also used as a basis for vaccine development. For these reasons, it is crucial to understand its molecular basis. In… read more here.
Keywords: memory characteristics; characteristics innate; immune memory; memory ... See more keywords
The distinct MHC‐unrestricted immunobiology of innate‐like and adaptive‐like human γδ T cell subsets—Nature's CAR‐T cells
Sign Up to like & getrecommendations! Published in 2020 at "Immunological Reviews"
DOI: 10.1111/imr.12928
Abstract: Distinct innate‐like and adaptive‐like immunobiological paradigms are emerging for human γδ T cells, supported by a combination of immunophenotypic, T cell receptor (TCR) repertoire, functional, and transcriptomic data. Evidence of the γδ TCR/ligand recognition modalities… read more here.
Keywords: adaptive like; like adaptive; biology; innate like ... See more keywords
High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.93814
Abstract: Cellular and humoral constituents of the immune system differ significantly between children and adults, yet very little is known about the impact of early-life pathogen exposure on this immunologic transition. We examined CD4+ and CD8+… read more here.
Keywords: pathogen; cd8; pathogen burden; promotes development ... See more keywords
Natural killer T cells and other innate-like T lymphocytes as emerging platforms for allogeneic cancer cell therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022016201
Abstract: T cells expressing chimeric antigen receptors (CARs) have achieved major clinical successes in patients with hematologic malignancies. However, these treatments remain largely ineffective in solid cancers and require significant time and resources to manufacture in… read more here.
Keywords: cell; cancer; natural killer; killer cells ... See more keywords
Innate-like T cells in children with sickle cell disease
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DOI: 10.1371/journal.pone.0219047
Abstract: Background The implication of lymphocytes in sickle cell disease pathogenesis is supported by a number of recent reports. These studies provided evidence for the activation of invariant natural killer T (iNKT) cells in adult patients,… read more here.
Keywords: frequency; cell disease; innate like; cell ... See more keywords
Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00756
Abstract: Mucosal-associated invariant T (MAIT) cells are innate-like T cells abundant in humans that can be activated in a TCR-independent manner by inflammatory and antiviral cytokines. In humans, the capacity for TCR-independent activation is functionally linked… read more here.
Keywords: cytokine; mait cells; mucosal associated; innate like ... See more keywords
The Interplay Between Innate-Like B Cells and Other Cell Types in Autoimmunity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01064
Abstract: Studies performed in animal models and in humans indicate that the innate arm of the immune system provides an essential role in the initial protection against potential insults and in maintaining tolerance to self-antigens. In… read more here.
Keywords: innate; interplay innate; like cells; innate like ... See more keywords