Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1
Sign Up to like & getrecommendations! Published in 2020 at "Nature Microbiology"
DOI: 10.1038/s41564-020-0753-6
Abstract: To avoid innate sensing and immune control, human immunodeficiency virus type 1 (HIV-1) has to prevent the accumulation of viral complementary DNA species. Here, we show that the late HIV-1 accessory protein Vpu hijacks DNA… read more here.
Keywords: integration; vpu; dna repair; hiv ... See more keywords
Innate sensing and cellular metabolism: role in fine tuning antiviral immune responses.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiac011
Abstract: Several studies over the last decade have identified intimate links between cellular metabolism and macrophage function. Metabolism has been shown to both drive and regulate macrophage function by producing bioenergetic and biosynthetic precursors as well… read more here.
Keywords: metabolism; immune responses; cellular metabolism; macrophage function ... See more keywords
Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.00967-20
Abstract: Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral… read more here.
Keywords: innate sensing; vpu; hiv; hiv vpu ... See more keywords