Inhibition of specific signaling pathways rather than epigenetic silencing of effector genes is the leading mechanism of innate tolerance
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DOI: 10.3389/fimmu.2023.1006002
Abstract: Introduction Macrophages activated through a pattern-recognition receptor (PRR) enter a transient state of tolerance characterized by diminished responsiveness to restimulation of the same receptor. Signaling-based and epigenetic mechanisms are invoked to explain this innate tolerance.… read more here.
Keywords: silencing effector; inhibition; innate tolerance; tolerance ... See more keywords