Cellular distribution of the Fragile X mental retardation protein in the inner ear: a developmental and comparative study in the mouse, rat, gerbil, and chicken
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25420
Abstract: The Fragile X mental retardation protein (FMRP) is an mRNA binding protein that is essential for neural circuit assembly and synaptic plasticity. Loss of functional FMRP leads to Fragile X syndrome (FXS), a neurodevelopmental disorder… read more here.
Keywords: fragile mental; inner ear; mental retardation; fmrp ... See more keywords
Transplantation of Ears Provides Insights into Inner Ear Afferent Pathfinding Properties
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22629
Abstract: Numerous tissue transplantations have demonstrated that otocysts can develop into normal ears in any location in all vertebrates tested thus far, though the pattern of innervation of these transplanted ears has largely been understudied. Here,… read more here.
Keywords: afferents navigate; inner ear; transplanted ears; ear afferents ... See more keywords
Comparative assessment of Fgf's diverse roles in inner ear development: A zebrafish perspective
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Dynamics"
DOI: 10.1002/dvdy.343
Abstract: Progress in understanding mechanisms of inner ear development has been remarkably rapid in recent years. The research community has benefited from the availability of several diverse model organisms, including zebrafish, chick, and mouse. The complexity… read more here.
Keywords: ear development; inner ear; development zebrafish; assessment fgf ... See more keywords
Retinoic acid signaling regulates late stages of semicircular canal morphogenesis and otolith maintenance in the zebrafish inner ear
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.510
Abstract: The vitamin A derivative all‐trans retinoic acid (RA) regulates early stages of inner ear development. As the early disruption of the RA pathway results in profound mispatterning of the developing inner ear, this confounds analyses… read more here.
Keywords: signaling regulates; inner ear; acid signaling; retinoic acid ... See more keywords
Gfi1‐GCE inducible Cre line for hair cell‐specific gene manipulation in mouse inner ear
Sign Up to like & getrecommendations! Published in 2019 at "genesis"
DOI: 10.1002/dvg.23304
Abstract: Tissue‐specific inducible Cre recombinase mouse lines allow precise genetic manipulations in spatiotemporal manners and are pivotal for functional studies of genes during development and in adults. Growth factor independence 1 (GFI1) is an essential transcription… read more here.
Keywords: inner ear; hair; gfi1; gfi1 gce ... See more keywords
Balance function after cochlear implant and inner ear anomaly: Comparison of dynamic posturography
Sign Up to like & getrecommendations! Published in 2020 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.394
Abstract: Patients with sensorineural hearing loss suffer concomitant vestibular dysfunction that is more prevalent in patients with inner ear anomaly and could be aggravated with cochlear implantation. To assess the vestibular dysfunction in patients with cochlear… read more here.
Keywords: balance function; inner ear; ear anomaly; cochlear implant ... See more keywords
Effect of inner ear malformations on intraoperative ECAP thresholds and postoperative auditory performance
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.836
Abstract: This study sought to characterize the influence of inner ear malformations (IEMs) on intraoperative electrically evoked compound action potential (ECAP) and auditory performance to better understand the underlying pathophysiology related to variabilities in cochlear implant… read more here.
Keywords: auditory performance; inner ear; ecap; ear malformations ... See more keywords
A novel three‐step process for the identification of inner ear malformation types
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.936
Abstract: We hypothesize that visualizing inner‐ear systematically in both cochlear view (oblique coronal plane) and in mid‐modiolar section (axial plane) and following three sequential steps simplifies, identification of inner‐ear malformation types. read more here.
Keywords: malformation types; inner ear; ear malformation; novel three ... See more keywords
Adhesive and Injectable Hydrogel Microspheres for Inner Ear Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202106591
Abstract: The least damaging and most economical method to deliver drugs or carriers into the inner ear for treatment of disease is through the middle ear. However, the retention of drug in the middle ear is… read more here.
Keywords: adhesive injectable; inner ear; ear treatment; treatment ... See more keywords
Novel Nanoencapsulation Technology and its Potential Role in Bile Acid-Based Targeted Gene Delivery to the Inner Ear.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202204986
Abstract: Hearing loss impacts a large proportion of the global population. Damage to the inner ear, in particular the sensitive hair cells, can impact individuals for the rest of their lives. There are very limited options… read more here.
Keywords: inner ear; nanoencapsulation; targeted gene; gene delivery ... See more keywords
Directed Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Sensory Epithelia in 3D Culture.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6949-4_6
Abstract: The inner ear sensory epithelium harbors mechanosensory hair cells responsible for detecting sound and maintaining balance. This protocol describes a three-dimensional (3D) culture system that efficiently generates inner ear sensory epithelia from aggregates of mouse… read more here.
Keywords: inner ear; sensory epithelia; mouse embryonic; ear sensory ... See more keywords