Optimized Tuning of Auditory Inner Hair Cells to Encode Complex Sound through Synergistic Activity of Six Independent K+ Current Entities.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107869
Abstract: Auditory inner hair cells (IHCs) convert sound vibrations into receptor potentials that drive synaptic transmission. For the precise encoding of sound qualities, receptor potentials are shaped by K+ conductances tuning the properties of the IHC… read more here.
Keywords: hair cells; encode complex; sound; current entities ... See more keywords
Concurrent gradients of ribbon volume and AMPA-receptor patch volume in cochlear afferent synapses on gerbil inner hair cells
Sign Up to like & getrecommendations! Published in 2018 at "Hearing Research"
DOI: 10.1016/j.heares.2018.03.028
Abstract: &NA; The Mongolian gerbil is a classic animal model for age‐related hearing loss. As a prerequisite for studying age‐related changes, we characterized cochlear afferent synaptic morphology in young adult gerbils, using immunolabeling and quantitative analysis… read more here.
Keywords: ampa; cochlear afferent; volume; hair ... See more keywords
Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06307-w
Abstract: In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory… read more here.
Keywords: hair cells; inner hair; mature inner; efferent innervation ... See more keywords
Tinnitus development is associated with synaptopathy of inner hair cells in Mongolian gerbils
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15334
Abstract: Human hearing loss (HL) is often accompanied by comorbidities like tinnitus, which is affecting up to 15% of the adult population. Rodent animal studies could show that tinnitus may not only be a result of… read more here.
Keywords: synaptopathy inner; hair cells; hair; behavioral signs ... See more keywords
Precision patterning: How inner hair cells “hop” to it
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adg8662
Abstract: A combination of Notch-mediated lateral inhibition, mechanical forces, and differential adhesion generates a single row of alternating inner hair and supporting cells. read more here.
Keywords: inner hair; hair cells; hair; patterning inner ... See more keywords
Tsukushi is essential for the development of the inner ear
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Brain"
DOI: 10.1186/s13041-020-00570-z
Abstract: Tsukushi (TSK)—a small, secreted, leucine-rich-repeat proteoglycan—interacts with and regulates essential cellular signaling cascades. However, its functions in the mouse inner ear are unknown. In this study, measurement of auditory brainstem responses, fluorescence microscopy, and scanning… read more here.
Keywords: inner ear; microscopy; hair cells; inner hair ... See more keywords
AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.236737
Abstract: ABSTRACT High-throughput neurotransmission at ribbon synapses of cochlear inner hair cells (IHCs) requires tight coupling of neurotransmitter release and balanced recycling of synaptic vesicles (SVs) as well as rapid restoration of release sites. Here, we… read more here.
Keywords: hair cells; clearance; cochlear inner; inner hair ... See more keywords
Disruption of Otoferlin Alters the Mode of Exocytosis at the Mouse Inner Hair Cell Ribbon Synapse
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00492
Abstract: Sound encoding relies on Ca2+-mediated exocytosis at the ribbon synapse between cochlear inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs). Otoferlin, a multi-C2 domain protein, is proposed to regulate Ca2+-triggered exocytosis at… read more here.
Keywords: synapse; inner hair; ribbon synapse; exocytosis ... See more keywords
Differential Gene Expression Patterns Between Apical and Basal Inner Hair Cells Revealed by RNA-Seq
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00332
Abstract: Tonotopic differences in the structure and physiological function, e.g., synapse number, membrane properties, Ca2+ channels, Ca2+ dependence of exocytosis and vesicle pool replenishment of inner hair cells (IHCs) along the longitudinal cochlear axis have recently… read more here.
Keywords: hair cells; expression patterns; gene expression; expression ... See more keywords