Aberrant adaptation of the inner medullary collecting ducts results in sodium retention and hypernatremia in a thick ascending limb specific Myh9 and Myh10 conditional knockout mouse model
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DOI: 10.1152/physiol.2023.38.s1.5729973
Abstract: Sodium reabsorption in the thick ascending limb (TAL) epithelium is essential to generate and sustain the interstitial osmotic gradient, which facilitates water reabsorption in the adjacent collecting duct system. Impaired TAL function can compromise this… read more here.
Keywords: myh9; physiology; inner medullary; weeks age ... See more keywords
Abstract 082: Histone Deacetylase 1 Activates Renal Inner-Medullary Nitric Oxide Production
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DOI: 10.1161/hyp.74.suppl_1.082
Abstract: Fluid flow along the renal nephron, particularly within the inner-medullary collecting duct (IMCD), increases in response to high salt intake. We previously showed in a series of reports that high salt intake increases nitric oxide… read more here.
Keywords: production; group; inner medullary; hdac1 ... See more keywords
Abstract P198: High Glucose Degrades (PRO) Renin Receptor by Autophagy and Ubiquitin Proteasome System in Inner Medullary Collecting Duct Cells
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DOI: 10.1161/hyp.74.suppl_1.p198
Abstract: Previously we reported high glucose (HG) regulation of PRR expression in the kidney. However, in contrast to the observed increase in PRR expression in mesangial cells and podocytes, its expression decreased in distal tubules in… read more here.
Keywords: medullary collecting; inner medullary; autophagy ubiquitin; expression ... See more keywords
Phosphatases Decrease Water and Urea Permeability in Rat Inner Medullary Collecting Ducts
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DOI: 10.3390/ijms24076537
Abstract: We previously showed that the phosphatases PP1/PP2A and PP2B dephosphorylate the water channel, AQP2, suggesting their role in water reabsorption. In this study, we investigated whether protein phosphatase 2A (PP2A) and protein phosphatase 2B (PP2B… read more here.
Keywords: water; osmotic water; water permeability; inner medullary ... See more keywords