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   Articles with "ino80" as a keyword



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Nuclear actin switch of the INO80 remodeler

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recommendations! Published in 2019 at "Journal of Molecular Cell Biology"

DOI: 10.1093/jmcb/mjy083

Abstract: Eukaryotic DNA is wrapped in nucleosomes, which impede the access of transcription factors and regulatory proteins to template DNA. Chromatin remodelers utilize the energy from ATP hydrolysis to drive histone movement relative to nucleosomal DNA… read more here.

Keywords: ino80; dna; willhoft 2018; switch ... See more keywords

INO80 promotes H2A.Z occupancy to regulate cell fate transition in pluripotent stem cells.

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recommendations! Published in 2021 at "Nucleic acids research"

DOI: 10.1093/nar/gkab476

Abstract: The INO80 chromatin remodeler is involved in many chromatin-dependent cellular functions. However, its role in pluripotency and cell fate transition is not fully defined. We examined the impact of Ino80 deletion in the naïve and… read more here.

Keywords: h2a occupancy; ino80; cell fate; transition ... See more keywords

INO80 participates in the pathogenesis of recurrent miscarriage by epigenetically regulating trophoblast migration and invasion

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recommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.16322

Abstract: The INO80 complex, a SWI/SNF family chromatin remodeler, has regulatory effects on ESC self‐renewal, somatic cell reprogramming and blastocyst development. However, the role of INO80 in regulating trophoblast cells and recurrent miscarriage (RM) remains elusive.… read more here.

Keywords: ino80; recurrent miscarriage; invasion; migration invasion ... See more keywords
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ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.adc8911

Abstract: Epigenetic dysregulation of cell cycle is a hallmark of tumorigenesis in multiple cancers, including hepatocellular carcinoma (HCC). Nonetheless, the epigenetic mechanisms underlying the aberrant cell cycle signaling and therapeutic response remain unclear. Here, we used… read more here.

Keywords: tumor progression; ino80; hcc; cell cycle ... See more keywords

Structural mechanism of extranucleosomal DNA readout by the INO80 complex

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.add3189

Abstract: The nucleosomal landscape of chromatin depends on the concerted action of chromatin remodelers. The INO80 remodeler specifically places nucleosomes at the boundary of gene regulatory elements, which is proposed to be the result of an… read more here.

Keywords: ino80; dna; structural mechanism; extranucleosomal dna ... See more keywords

The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A.Z and repress autophagy

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recommendations! Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.ade8312

Abstract: Autophagy is a critical process to maintain homeostasis, differentiation, and development. How autophagy is tightly regulated by nutritional changes is poorly understood. Here, we identify chromatin remodeling protein Ino80 and histone variant H2A.Z as the… read more here.

Keywords: ino80; torc1; repress; rpd3l complex ... See more keywords