Growth productivity as a determinant of the inoculum effect for bactericidal antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add0924
Abstract: Understanding the mechanisms by which populations of bacteria resist antibiotics has implications in evolution, microbial ecology, and public health. The inoculum effect (IE), where antibiotic efficacy declines as the density of a bacterial population increases,… read more here.
Keywords: growth; growth productivity; bactericidal antibiotics; inoculum effect ... See more keywords
Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis
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DOI: 10.1128/aac.00324-17
Abstract: ABSTRACT Certain Staphylococcus aureus strains exhibit an inoculum effect (InE) with cefazolin (CFZ) that has been associated with therapeutic failures in high-inoculum infections. We assessed the in vitro activities of ceftaroline (CPT), CFZ, and nafcillin… read more here.
Keywords: cfz; staphylococcus aureus; cpt; inoculum effect ... See more keywords
The carbapenem inoculum effect provides insights into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales
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DOI: 10.1128/mbio.01540-25
Abstract: ABSTRACT Carbapenem-resistant Enterobacterales (CRE) are important pathogens that can develop resistance via multiple molecular mechanisms, including hydrolysis or reduced antibiotic influx. Identifying these mechanisms can improve pathogen surveillance, infection control, and patient care. We investigated,… read more here.
Keywords: resistance; carbapenemase; inoculum effect; carbapenem ... See more keywords