Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway
Sign Up to like & getrecommendations! Published in 2022 at "Redox Biology"
DOI: 10.1016/j.redox.2022.102266
Abstract: Background Renal fibrosis, associated with oxidative stress and nitric oxide (NO) deficiency, contributes to the development of chronic kidney disease and renal failure. As major energy source in maintaining renal physiological functions, tubular epithelial cells… read more here.
Keywords: nitrate nitrite; lipid metabolism; inorganic nitrate; fibrosis ... See more keywords
Functional mouth rinse containing inorganic nitrate and antioxidants bolsters the enterosalivary pathway and lowers blood pressure in Wistar rats
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DOI: 10.1038/s41598-025-12060-0
Abstract: The enterosalivary pathway generates systemic nitric oxide from dietary nitrate for vasodilation and blood pressure (BP) regulation, but standard antibacterial mouth rinses may disrupt this process. This study evaluated a bioactive mouth rinse infused with… read more here.
Keywords: enterosalivary pathway; rinse; nitrate; inorganic nitrate ... See more keywords
A pro-resolving phenotype underpins the anti-inflammatory effects of inorganic nitrate
Sign Up to like & getrecommendations! Published in 2021 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehab724.3352
Abstract: Increasing evidence highlights the critical role of chronic inflammation in cardiovascular disease (CVD). Targeting inflammatory pathways in patients with CVD has been associated with improved CV function in pre-clinical (Gee, 2017), early clinical (Yndestad, 2006;… read more here.
Keywords: anti inflammatory; inorganic nitrate; pro resolving; inflammation ... See more keywords
0089 Pre-Sleep Inorganic Nitrate Use and Sleep Quality: A Pilot Study
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DOI: 10.1093/sleep/zsaf090.0089
Abstract: Poor sleep quality is bidirectionally associated with cardiovascular and neurocognitive disorders. Preclinical data implicate nitric oxide (NO) in the onset, and maintenance, of sleep. Acute inorganic nitrate supplementation increases NO bioavailability via serial reduction for… read more here.
Keywords: quality; pre sleep; inorganic nitrate; sleep quality ... See more keywords
Acute interaction between oral glucose (75 g as Lucozade) and inorganic nitrate: Decreased insulin clearance, but lack of blood pressure‐lowering
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13913
Abstract: Dietary inorganic nitrate (NO3−) lowers peripheral blood pressure (BP) in healthy volunteers, but lacks such effect in individuals with, or at risk of, type 2 diabetes mellitus (T2DM). Whilst this is commonly assumed to be… read more here.
Keywords: acute interaction; inorganic nitrate; blood pressure;
Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00850.2019
Abstract: BACKGROUND Chronic under perfusion of the skeletal muscle tissues is a contributor to decreased exercise capacity in patients with heart failure reduced ejection fraction (HFrEF. This under perfusion is due, at least in part, to… read more here.
Keywords: function; inorganic nitrate; exercise capacity;