Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.12.019
Abstract: We have previously demonstrated that inorganic polyphosphate (polyP) is a potent activator of the mitochondrial permeability transition pore (mPTP) in cardiac myocytes. PolyP depletion protected against Ca2+-induced mPTP opening, however it did not prevent and… read more here.
Keywords: polyp; chain; cardiac myocytes; inorganic polyphosphate ... See more keywords
Dual Role of Inorganic Polyphosphate (POLYP) in the Regulation of Mitochondria-Dependent Cell Death
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2345
Abstract: Inorganic polyphosphate (polyP) is a ubiquitous biological polymer that is well-conserved throughout the evolution and various species. Isoenergetic with ATP, polyP is composed of multiple subunits of orthophosphate, linked together by phosphoanhydride bonds. PolyP plays… read more here.
Keywords: polyp; inorganic polyphosphate; role; cell death ... See more keywords
Enzymatic phosphorylation of mannose by glucomannokinase from Mycobacterium phlei using inorganic polyphosphate.
Sign Up to like & getrecommendations! Published in 2017 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2017.05.006
Abstract: Mannose-6-phosphate is an important phosphor-sugar, which is involved in many physiological functions and it is used to treat many diseases. Its production is however expensive since it requires costly substrate ATP as phosphorylation agent. This… read more here.
Keywords: glucomannokinase; inorganic polyphosphate; mycobacterium phlei; using inorganic ... See more keywords
Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration?
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105211
Abstract: Mitochondrial dysfunction - including increased apoptosis, calcium and protein dyshomeostasis within the organelle, and dysfunctional bioenergetics and oxidative status - is a common and early feature in all the major neurodegenerative diseases, including Alzheimer's Disease… read more here.
Keywords: polyp; inorganic polyphosphate; neurodegeneration; physiology ... See more keywords
Inorganic polyphosphate from the immunobiotic Lactobacillus rhamnosus CRL1505 prevents inflammatory response in the respiratory tract
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.06.010
Abstract: Lactobacillus (L.) rhamnosus CRL1505 accumulates inorganic polyphosphate (polyP) in its cytoplasm in response to environmental stress. The aim of this study was to evaluate the potential effects of polyP from the immunobiotic CRL1505 on an… read more here.
Keywords: crl1505; inorganic polyphosphate; response; lactobacillus rhamnosus ... See more keywords
Preferential utilization of inorganic polyphosphate over other bioavailable phosphorus sources by the model diatoms Thalassiosira spp.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Microbiology"
DOI: 10.1111/1462-2920.14630
Abstract: Summary Polyphosphates and phosphomonoesters are dominant components of marine dissolved organic phosphorus (DOP). Collectively, DOP represents an important nutritional phosphorus (P) source for phytoplankton growth in the ocean, but the contribution of specific DOP sources… read more here.
Keywords: thalassiosira spp; inorganic polyphosphate; polyphosphate bioavailable; phosphorus ... See more keywords
Interactions between DksA and Stress-Responsive Alternative Sigma Factors Control Inorganic Polyphosphate Accumulation in Escherichia coli
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bacteriology"
DOI: 10.1128/jb.00133-20
Abstract: Inorganic polyphosphate (polyP) is an evolutionarily ancient, widely conserved biopolymer required for stress resistance and pathogenesis in diverse bacteria, but we do not understand how its synthesis is regulated. In this work, I gained new… read more here.
Keywords: sigma factors; inorganic polyphosphate; polyp; stress ... See more keywords
Inorganic Polyphosphate: Coacervate Formation and Functional Significance in Nanomedical Applications
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s389819
Abstract: Abstract Inorganic polyphosphates (polyP) are long-chain polymers of orthophosphate residues, which, depending on the external conditions, can be present both physiologically and synthetically in either soluble, nanoparticulate or coacervate form. In recent years, these polymers… read more here.
Keywords: polyphosphate coacervate; coacervate formation; coacervate; inorganic polyphosphate ... See more keywords
Mitochondrial Inorganic Polyphosphate (polyP) Is a Potent Regulator of Mammalian Bioenergetics in SH-SY5Y Cells: A Proteomics and Metabolomics Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.833127
Abstract: Inorganic polyphosphate (polyP) is an ancient, ubiquitous, and well-conserved polymer which is present in all the studied organisms. It is formed by individual subunits of orthophosphate which are linked by structurally similar bonds and isoenergetic… read more here.
Keywords: polyphosphate polyp; inorganic polyphosphate; physiology; polyp ... See more keywords
Enzymatic Depletion of Mitochondrial Inorganic Polyphosphate (polyP) Increases the Generation of Reactive Oxygen Species (ROS) and the Activity of the Pentose Phosphate Pathway (PPP) in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11040685
Abstract: Inorganic polyphosphate (polyP) is an ancient biopolymer that is well preserved throughout evolution and present in all studied organisms. In mammals, it shows a high co-localization with mitochondria, and it has been demonstrated to be… read more here.
Keywords: mitoppx cells; ppp; inorganic polyphosphate; mammalian cells ... See more keywords
Inorganic Polyphosphate—Regulator of Cellular Metabolism in Homeostasis and Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040913
Abstract: Inorganic polyphosphate (polyP), a simple anionic polymer consisting of even hundreds of orthophosphate units, is a universal molecule present in both simple and complex organisms. PolyP controls homeostatic processes in animals, such as blood coagulation,… read more here.
Keywords: polyphosphate; metabolism; inorganic polyphosphate; homeostasis ... See more keywords