The protective effect of inosine against rotenone-induced Parkinson’s disease in mice; role of oxido-nitrosative stress, ERK phosphorylation, and A2AR expression
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DOI: 10.1007/s00210-019-01804-1
Abstract: Parkinson’s disease (PD) is a severe disabling syndrome in which neuroinflammation and various signaling pathways are believed to mediate dopaminergic neurodegeneration. Here, the possible disease-modifying effects of the purine nucleoside inosine were examined against rotenone-induced… read more here.
Keywords: a2ar expression; disease; effect; inosine ... See more keywords
Substitution of dietary fishmeal by soybean meal with inosine administration influences growth, digestibility, immunity, stress resistance and gut morphology of juvenile amberjack Seriola dumerili
Sign Up to like & getrecommendations! Published in 2018 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2018.01.037
Abstract: Abstract We determined the dietary inosine effects in gradually replaced fishmeal (FM) with soybean meal (SBM) protein-based diets on growth, digestibility, immunity, stress resistance and gut morphology of juvenile amberjack. Seven experimental diets were formulated… read more here.
Keywords: inosine; stress resistance; growth; digestibility ... See more keywords
Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.06.046
Abstract: Endonuclease V (EndoV) cleaves the second phosphodiester bond 3' to a deaminated adenosine (inosine). Although highly conserved, EndoV homologs change substrate preference from DNA in bacteria to RNA in eukaryotes. We have characterized EndoV from… read more here.
Keywords: endonuclease; inosine specific; endov homologs; inosine ... See more keywords
Inosine Substitutions in RNA Activate Latent G-Quadruplexes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c05214
Abstract: It is well-accepted that gene expression is heavily influenced by RNA structure. For instance, stem-loops and G-quadruplexes (rG4s) are dynamic motifs in mRNAs that influence gene expression. Adenosine-to-inosine (A-to-I) editing is a common chemical modification… read more here.
Keywords: substitutions rna; inosine substitutions; gene expression; inosine ... See more keywords
European COST action CA16120 EPITRAN: the first four years and beyond
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DOI: 10.1080/15476286.2021.1982121
Abstract: How do you measure the success of a venture? One simple method is to count the number of participants involved. Using this criterion, the COST action CA16120 EPITRAN, which focuses on the research of the… read more here.
Keywords: action; inosine; field; cost ... See more keywords
ALSUntangled No. 37: Inosine*
Sign Up to like & getrecommendations! Published in 2017 at "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"
DOI: 10.1080/21678421.2016.1223270
Abstract: Urate (sometimes referred to as uric acid) is a naturally occurring antioxidant (5,6). Interest in urate as a possible neuroprotective agent began when researchers noted that high urate levels are associated with lower risk of… read more here.
Keywords: alsuntangled inosine; inosine; disease;
Inosine RNA modifications are enriched at the codon wobble position in mouse oocytes and eggs†
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioz130
Abstract: Abstract Mammalian oocytes and eggs are transcriptionally quiescent and depend on post-transcriptional mechanisms for proper maturation. Post-transcriptional mRNA modifications comprise an important regulatory mechanism that can alter protein and miRNA recognition sites, splicing, stability, secondary… read more here.
Keywords: inosine; oocytes eggs; enriched codon; wobble position ... See more keywords
Inosine alleviates depression-like behavior and increases the activity of the ERK-CREB signaling in adolescent male rats
Sign Up to like & getrecommendations! Published in 2018 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001101
Abstract: Inosine, a major breakdown product of adenosine by the enzyme adenosine deaminase, binds to adenosine receptors and initiates intracellular signaling events. Adenosine and inosine have already been described as capable of modulating depression-like behavior in… read more here.
Keywords: like behavior; inosine; erk creb; activity ... See more keywords
Inosine supplementation effectively provokes the growth, immune response, oxidative stress resistance and intestinal morphology of juvenile red sea bream, Pagrus major
Sign Up to like & getrecommendations! Published in 2017 at "Aquaculture Nutrition"
DOI: 10.1111/anu.12463
Abstract: A feeding trial was conducted to determine effects of dietary inosine on growth, immune responses, oxidative stress resistance and intestinal morphology of juvenile red sea bream. A semi-purified basal diet supplemented with 0 (D1, control),… read more here.
Keywords: inosine; growth; inosine supplementation; oxidative stress ... See more keywords
Microbial Inosine Promotes Immune-Checkpoint Blockade Response in Mice.
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DOI: 10.1158/2159-8290.cd-rw2020-120
Abstract: Inosine produced by the gut microbe Bifidobacterium pseudolongum enhanced anti-CTLA4's efficacy. read more here.
Keywords: immune checkpoint; inosine promotes; promotes immune; checkpoint blockade ... See more keywords
Succinate and inosine coordinate innate immune response to bacterial infection
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010796
Abstract: Macrophages restrict bacterial infection partly by stimulating phagocytosis and partly by stimulating release of cytokines and complement components. Here, we treat macrophages with LPS and a bacterial pathogen, and demonstrate that expression of cytokine IL-1β… read more here.
Keywords: inosine; coordinate innate; bacterial infection; inosine coordinate ... See more keywords