Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5′‐monophosphate dehydrogenase (HpIMPDH) inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21467
Abstract: Inosine 5′‐monophosphate dehydrogenase (IMPDH) catalyzes a crucial step in the biosynthesis of guanine nucleotides. Being a validated target for immunosuppressive, antiviral, and anticancer drug development, lately it has been exploited as a promising target for… read more here.
Keywords: hpimpdh inhibitors; monophosphate dehydrogenase; hpimpdh; inosine monophosphate ... See more keywords
Inosine monophosphate dehydrogenase type1 sustains tumor growth in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24416
Abstract: BACKGROUND Inosine monophosphate dehydrogenase (IMPDH) is the key enzyme in the biosynthesis of purine nucleotides. IMPDH1 and IMPDH2 are the two isoforms of IMPDH and they share 84% amino acid similarity and virtually indistinguishable catalytic… read more here.
Keywords: hepatocellular carcinoma; growth; monophosphate dehydrogenase; inosine monophosphate ... See more keywords
Detection of Inosine Monophosphate (IMP) in Meat Using Double-Enzyme Sensor
Sign Up to like & getrecommendations! Published in 2019 at "Food Analytical Methods"
DOI: 10.1007/s12161-019-01652-y
Abstract: Inosine monophosphate (IMP) was considered to be an important component of meat flavor and an important indicator for evaluating the quality of meat products. This paper developed a novel dual-enzyme biosensor for the quantitative detection… read more here.
Keywords: imp; detection; double enzyme; enzyme ... See more keywords
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.06.005
Abstract: Small cell lung cancer (SCLC) is a rapidly lethal disease with few therapeutic options. We studied metabolic heterogeneity in SCLC to identify subtype-selective vulnerabilities. Metabolomics in SCLC cell lines identified two groups correlating with high… read more here.
Keywords: sclc; monophosphate dehydrogenase; cell lung; inosine monophosphate ... See more keywords
Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.7b01622
Abstract: Tuberculosis (TB) remains a major cause of mortality worldwide, and improved treatments are needed to combat emergence of drug resistance. Inosine 5′-monophosphate dehydrogenase (IMPDH), a crucial enzyme required for de novo synthesis of guanine nucleotides,… read more here.
Keywords: monophosphate dehydrogenase; impdh; fragment based; inosine monophosphate ... See more keywords
The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections.
Sign Up to like & getrecommendations! Published in 2021 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00342
Abstract: Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs have been reported, relatively few have… read more here.
Keywords: staphylococcus aureus; monophosphate dehydrogenase; target; antibacterial activity ... See more keywords
Thermal stabilities of inosine monophosphate-degrading enzymes in several fish muscles
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Food Properties"
DOI: 10.1080/10942912.2020.1785492
Abstract: ABSTRACT The compositions and inosinic acid contents of ATP-related compounds in various processed fish meat products were examined in this study. Moreover, the relationships between these variables and the heating processes used on the products… read more here.
Keywords: inosine monophosphate; fish meat; meat products; inosinic acid ... See more keywords
Mechanism of Inosine Monophosphate Degradation by Specific Spoilage Organism from Grass Carp in Fish Juice System
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DOI: 10.3390/foods11172672
Abstract: Microbial growth strongly affects the quality and flavor of fish and fish products. This study aimed to explore the role and function of grass carp-borne microorganisms in the degradation of inosine monophosphate (IMP) related compounds… read more here.
Keywords: fish juice; inosine monophosphate; grass carp; degradation ... See more keywords
Evaluation of Bronopol and Disulfiram as Potential Candidatus Liberibacter asiaticus Inosine 5′-Monophosphate Dehydrogenase Inhibitors by Using Molecular Docking and Enzyme Kinetic
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25102313
Abstract: Citrus huanglongbing (HLB) is a destructive disease that causes significant damage to many citrus producing areas worldwide. To date, no strategy against this disease has been established. Inosine 5′-monophosphate dehydrogenase (IMPDH) plays crucial roles in… read more here.
Keywords: bronopol disulfiram; molecular docking; inosine monophosphate; monophosphate dehydrogenase ... See more keywords