Adenosine-to-Inosine RNA Editing and N6-Methyladenosine Modification Modulating Expression of Drug Metabolizing Enzymes
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DOI: 10.1124/dmd.121.000390
Abstract: Interindividual differences in the expression and activity of drug metabolizing enzymes including cytochrome P450, UDP-glucuronosyltransferase, and esterases cause variable therapeutic efficacy or adverse events of drugs. As the major mechanisms causing the variability in the… read more here.
Keywords: drug metabolizing; inosine rna; drug; adenosine inosine ... See more keywords
Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development
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DOI: 10.1242/jcs.200055
Abstract: ABSTRACT Adenosine to inosine (A-to-I) RNA editing is important for a functional brain, and most known sites that are subject to selective RNA editing have been found to result in diversified protein isoforms that are… read more here.
Keywords: adenosine inosine; rna; adar2; inosine rna ... See more keywords
Development and Validation of a Four Adenosine-to-Inosine RNA Editing Site-Relevant Prognostic Signature for Assessing Survival in Breast Cancer Patients
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DOI: 10.3389/fonc.2022.861439
Abstract: Background Adenosine-to-inosine RNA editing (ATIRE) is increasingly being used to characterize cancer. However, no studies have been conducted to identify an ATIRE signature for predicting cancer survival. Methods Breast cancer (BRCA) samples with ATIRE profiles… read more here.
Keywords: cancer; validation; signature; atire ... See more keywords