Concise syntheses and some biological activities of dl‐2,5‐di‐O‐methyl‐chiro‐inositol, dl‐1,4‐di‐O‐methyl‐scyllo‐inositol, and dl‐1,6‐dibromo‐1,6‐dideoxy‐2,5‐di‐O‐methyl‐chiro‐inositol
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DOI: 10.1002/ardp.202000254
Abstract: The regio‐ and stereospecific synthesis of O‐methyl‐chiro‐inositols and O‐methyl‐scyllo‐inositol was achieved, starting from p‐benzoquinone. After preparing dimethoxy conduritol‐B as a key compound, regiospecific bromination of the alkene moiety of dimethoxy conduritol‐B and acid‐catalyzed ring opening… read more here.
Keywords: methyl chiro; inositol; chiro; chiro inositol ... See more keywords
An in vitro synthetic biology platform for the industrial biomanufacturing of myo‐inositol from starch
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DOI: 10.1002/bit.26314
Abstract: Myo‐Inositol (vitamin B8) is widely used in the drug, cosmetic, and food & feed industries. Here, we present an in vitro non‐fermentative enzymatic pathway that converts starch to inositol in one vessel. This in vitro… read more here.
Keywords: myo inositol; inositol; synthetic biology; biology platform ... See more keywords
Inositol monophosphatase 1 (IMPA1) promotes triple‐negative breast cancer progression through regulating mTOR pathway and EMT process
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DOI: 10.1002/cam4.4970
Abstract: Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, which is characterized by high heterogeneity and metabolic dysregulation. Inositol monophosphatase 1(IMPA1) is critical for the metabolism of inositol, which has profound effects… read more here.
Keywords: inositol; emt process; impa1; breast cancer ... See more keywords
2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐d‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids
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DOI: 10.1002/chir.23457
Abstract: Abstract Inositol phosphates and inositol phospholipids are ubiquitous in biochemistry and play a central role in cell signaling and regulation events. For this reason, their synthesis has attracted widespread interest. This paper describes the preparation… read more here.
Keywords: inositol; acetyl tetra; inositol phosphate; tetra benzyl ... See more keywords
Modification and application of an in vitro assay to examine inositol phosphate degradation in the digestive tract of poultry.
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DOI: 10.1002/jsfa.8297
Abstract: BACKGROUND An in vitro assay was modified to study the disappearance of inositol hexakisphosphate (InsP6 ) and the formation of lower inositol phosphate (InsP) isomers in the poultry digestive tract, and three experiments investigated the… read more here.
Keywords: inositol; vitro assay; inositol phosphate; digestive tract ... See more keywords
Metabolic Labeling of Inositol Phosphates and Phosphatidylinositols in Yeast and Mammalian Cells.
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DOI: 10.1007/978-1-0716-0167-9_7
Abstract: Inositol phosphate (IP) and phosphatidylinositol (PI) signaling are critical signal transduction pathways responsible for generating numerous receptor-mediated cellular responses. Biochemical and genetic studies have revealed diverse roles of IP and PI signaling in eukaryotic signaling,… read more here.
Keywords: inositol; phosphates phosphatidylinositols; labeling inositol; inositol phosphates ... See more keywords
Regulation of the inositol transporter Itr1p by hydrogen peroxide in Saccharomyces cerevisiae
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DOI: 10.1007/s00203-018-1584-1
Abstract: Myo-inositol is a precursor of several membrane phospholipids and sphingolipids and plays a key role in gene regulation in Saccharomyces cerevisiae (S. cerevisiae). Here, we tested whether H2O2 was affecting the levels of the inositol… read more here.
Keywords: inositol; saccharomyces cerevisiae; membrane; inositol transporter ... See more keywords
Plasma and urinary inositol isomer profiles measured by UHPLC-MS/MS reveal differences in scyllo-inositol levels between non-pregnant and pregnant women
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DOI: 10.1007/s00216-020-02919-8
Abstract: Previous studies support that myo- and d-chiro-inositol isomers are promising bioactives for the treatment of women with polycystic ovary syndrome and for lowering the risk of gestational diabetes mellitus in pregnant women, whereas scyllo-inositol may… read more here.
Keywords: inositol; pregnant women; pregnant pregnant; inositol isomer ... See more keywords
Urochloa ruziziensis cover crop increases the cycling of soil inositol phosphates
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DOI: 10.1007/s00374-018-1316-3
Abstract: Ruzigrass (Urochloa ruziziensis) is a cover crop that is commonly used in Brazil and exudes high concentrations of organic acids from its roots, and is therefore expected to mobilize soil organic P such as inositol… read more here.
Keywords: inositol; ruzigrass; inositol phosphates; cover ... See more keywords
Quantification of dietary inositol requirement for fingerling Channa punctatus (Bloch) based on growth, antioxidant status, hematological tools and liver inositol concentration
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DOI: 10.1016/j.aquaculture.2019.734280
Abstract: Abstract An experiment was carried out to estimate dietary inositol requirement of fingerling Channa punctatus (3.78 ± 0.21 g) by feeding purified diets (450 g kg −1 CP, 18.71 kJ g −1 GE) with eight doses of inositol (0, 100, 200, 300,… read more here.
Keywords: inositol; requirement fingerling; inositol requirement; dietary inositol ... See more keywords
Effects of combined inositol hexakisphosphate and inositol supplement on antioxidant activity and metabolic enzymes in the liver of streptozotocin-induced type 2 diabetic rats.
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DOI: 10.1016/j.cbi.2017.07.024
Abstract: Diabetes mellitus is associated with elevated reactive oxygen species, lipid abnormalities, reduced antioxidant activity and organ damage. This study examines the effects of combined inositol hexakisphosphate (IP6) and inositol supplement on antioxidant levels and other… read more here.
Keywords: inositol; type diabetic; ip6 inositol; inositol supplement ... See more keywords