Microbial degradation of myo-inositol hexakisphosphate (IP6): specificity, kinetics, and simulation
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DOI: 10.1007/s13205-018-1302-3
Abstract: Microbial degradation of myo-inositol hexakisphosphate (IP6) is crucial to deal with nutritional problems in monogastric animals as well as to prevent environmental phosphate pollution. The present study deals with the degradation of IP6 by microorganisms… read more here.
Keywords: myo inositol; degradation; inositol hexakisphosphate; degradation myo ... See more keywords
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Signalling"
DOI: 10.1016/j.cellsig.2018.03.001
Abstract: Diphosphoinositol pentakisphosphate (IP7) is critical for the exocytotic capacity of the pancreatic β-cell, but its regulation by the primary instigator of β-cell exocytosis, glucose, is unknown. The high Km for ATP of the IP7-generating enzymes,… read more here.
Keywords: insulin; inositol hexakisphosphate; sensor pancreatic; hexakisphosphate kinase ... See more keywords
MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia
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DOI: 10.1038/s41467-020-19919-y
Abstract: Inositol polyphosphates are vital metabolic and secondary messengers, involved in diverse cellular functions. Therefore, tight regulation of inositol polyphosphate metabolism is essential for proper cell physiology. Here, we describe an early-onset neurodegenerative syndrome caused by… read more here.
Keywords: inositol; accumulation; inositol hexakisphosphate; minpp1 ... See more keywords
Inositol Hexakisphosphate (IP6) Accelerates Immature HIV-1 Gag Protein Assembly toward Kinetically Trapped Morphologies
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DOI: 10.1101/2022.03.29.486265
Abstract: During the late stages of the HIV-1 lifecycle, immature virions are produced by the concerted activity of Gag polyproteins, primarily mediated by the capsid (CA) and spacer peptide 1 (SP1) domains, which assemble into a… read more here.
Keywords: gag; hexakisphosphate ip6; kinetically trapped; ip6 accelerates ... See more keywords
Atomic-scale characterization of mature HIV-1 capsid stabilization by inositol hexakisphosphate (IP6)
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DOI: 10.1126/sciadv.abc6465
Abstract: All-atom simulations reveal the molecular mechanisms of inositol hexakisphosphate binding to HIV capsids. Inositol hexakisphosphates (IP6) are cellular cofactors that promote the assembly of mature capsids of HIV. These negatively charged molecules coordinate an electropositive… read more here.
Keywords: inositol hexakisphosphate; hiv; atomic scale; capsid ... See more keywords
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity
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DOI: 10.1371/journal.pone.0188852
Abstract: Inositol pyrophosphates have been implicated in a wide range of cellular processes. Inositol hexakisphosphate kinase 1 catalyzes the pyrophosphorylation of inositol hexakisphosphate into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate which is important in numerous areas of cell physiology such… read more here.
Keywords: hexakisphosphate kinase; physiology; activity; inositol hexakisphosphate ... See more keywords