Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.10.010
Abstract: Liquid-liquid phase separation (LLPS) compartmentalizes transcriptional condensates for gene expression, but little is known about how this process is controlled. Here, we showed that depletion of IPMK, encoding inositol polyphosphate multikinase, promotes autophagy and lysosomal… read more here.
Keywords: phase separation; liquid phase; inositol polyphosphate; liquid liquid ... See more keywords
Prognostic Value of Inositol Polyphosphate-5-Phosphatase Expression in Recurrent and Metastatic Cutaneous Squamous Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2019.08.027
Abstract: BACKGROUND Inositol polyphosphate-5-phosphatase (INPP5A) has been shown to play a role in the progression of actinic keratosis to cutaneous squamous cell carcinoma (cSCC) and the progression of localized disease to metastatic disease. Currently, no cSCC… read more here.
Keywords: cell carcinoma; squamous cell; expression; polyphosphate phosphatase ... See more keywords
Dermoscopy and reflectance confocal microscopy features of acquired lymphangiectasias following surgery and radiotherapy of breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Dermatology"
DOI: 10.1111/ijd.15596
Abstract: 3 Maly CJ, Cumsky HJL, Costello CM, et al. Prognostic value of inositol polyphosphate-5-phosphatase expression in recurrent and metastatic cutaneous squamous cell carcinoma. J Am Acad Dermatol 2020; 82: 846–853. 4 Cumsky HJL, Costello CM,… read more here.
Keywords: microscopy; squamous cell; polyphosphate phosphatase; inositol polyphosphate ... See more keywords
The Expanding Significance of Inositol Polyphosphate Multikinase as a Signaling Hub
Sign Up to like & getrecommendations! Published in 2017 at "Molecules and Cells"
DOI: 10.14348/molcells.2017.0066
Abstract: The inositol polyphosphates are a group of multifunctional signaling metabolites whose synthesis is catalyzed by a family of inositol kinases that are evolutionarily conserved from yeast to humans. Inositol polyphosphate multikinase (IPMK) was first identified… read more here.
Keywords: inositol; inositol polyphosphate; expanding significance; polyphosphate multikinase ... See more keywords
Development and Evaluation of Low Phytic Acid Soybean by siRNA Triggered Seed Specific Silencing of Inositol Polyphosphate 6-/3-/5-Kinase Gene
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2018.00804
Abstract: Soybean is one of the leading oilseed crop in the world and is showing a remarkable surge in its utilization in formulating animal feeds and supplements. Its dietary consumption, however, is incongruent with its existing… read more here.
Keywords: phytic acid; seed; low phytic; polyphosphate kinase ... See more keywords
Ectopic Expression of Gs5PTase8, a Soybean Inositol Polyphosphate 5-Phosphatase, Enhances Salt Tolerance in Plants
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21031023
Abstract: Inositol polyphosphate 5-phosphatases (5PTases) function in inositol signaling by regulating the catabolism of phosphoinositol derivatives. Previous reports showed that 5PTases play a critical role in plant development and stress responses. In this study, we identified… read more here.
Keywords: inositol polyphosphate; ectopic expression; gs5ptase8; salt tolerance ... See more keywords
Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.73523
Abstract: Inositol polyphosphate multikinase (IPMK), a key enzyme in inositol polyphosphate (IP) metabolism, is a pleiotropic signaling factor involved in major biological events, including transcriptional control. In the yeast, IPMK and its IP products promote the… read more here.
Keywords: swi snf; embryonic stem; mouse embryonic; snf ... See more keywords