Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK.
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DOI: 10.1016/j.molcel.2021.08.025
Abstract: Mitochondrial dynamics regulated by mitochondrial fusion and fission maintain mitochondrial functions, whose alterations underline various human diseases. Here, we show that inositol is a critical metabolite directly restricting AMPK-dependent mitochondrial fission independently of its classical… read more here.
Keywords: ampk activation; fission; inositol serves; mitochondrial fission ... See more keywords