The adenylate cyclase activator forskolin potentiates the positive inotropic effect of the phosphodiesterase inhibitor milrinone but not of the calcium sensitizer levosimendan nor of its hemodynamically active metabolites: an apparent conundrum.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001235
Abstract: ABSTRACT OR-1855 and OR-1896 are two hemodynamically active metabolites of the inodilator levosimendan, with calcium sensitizing activity, but their mechanism of action is still not fully understood.It has been previously reported that the positive inotropic… read more here.
Keywords: inotropic effect; positive inotropic; forskolin; active metabolites ... See more keywords
Increased SERCA2a activity underlies the mechanism of positive inotropic effect of ivabradine.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental physiology"
DOI: 10.1113/ep087964
Abstract: NEW FINDINGS What is the central question of this study? Although ivabradine therapeutic effect on patients with chronic heart failure and chronic stable angina pectoris, is mediated through the reduction in heart rate, the hemodynamic… read more here.
Keywords: heart; positive inotropic; effect; inotropic effect ... See more keywords
Does glucagon have a positive inotropic effect in the human heart?
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Diabetology"
DOI: 10.1186/s12933-018-0791-z
Abstract: Glucagon is considered to exert cardiostimulant effects, most notably the enhancement of heart rate and contractility, due to the stimulation of glucagon receptors associated with Gs protein stimulation which causes adenylyl cyclase activation and the… read more here.
Keywords: effect human; glucagon; heart; positive inotropic ... See more keywords
Novel cilostamide analogs, phosphodiesterase 3 inhibitors, produce positive inotropic but differential lusitropic and chronotropic effects on isolated rat atria
Sign Up to like & getrecommendations! Published in 2017 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2017.8831
Abstract: Objective(s): Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect comparable to that of IBMX (3-isobutyl-1-methylxanthine), a non-selective PDE inhibitor, but… read more here.
Keywords: combination; chronotropic; phosphodiesterase; effect ... See more keywords