Structure-Based Design of Scaffolds Targeting PDE10A by INPHARMA-NMR.
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DOI: 10.1021/acs.jcim.7b00246
Abstract: Phosphodiesterases (PDE) hydrolyze both cyclic AMP and GMP (cAMP/cGMP) and are responsible for the regulation of their levels in a multitude of cellular functions. PDE10A is expressed in the brain and is a validated target… read more here.
Keywords: inpharma nmr; pde10a; structure based; inpharma ... See more keywords