Articles with "ins1 cells" as a keyword



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Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells.

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Published in 2018 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2018.10.020

Abstract: Elamipretide is a tetrapeptide that restores defects in mitochondrial function, binds to cardiolipin, and is being tested in clinical trials for mitochondria-related diseases. However, whether elamipretide modulates mitochondrial quality control and dynamics, processes essential to… read more here.

Keywords: mitophagosome formation; ins1 cells; cells elamipretide; nutrient excess ... See more keywords
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2189-P: Human IAPP Destabilizes IRF1 Protein to Reduce PD-L1 Expression in INS1 Cells

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Published in 2019 at "Diabetes"

DOI: 10.2337/db19-2189-p

Abstract: Background: Programmed death-ligand 1 (PD-L1) plays a critical role to protect β-cells against immune attack. Interferon regulatory factor 1 (IRF1) is a key transcriptional factor to regulate PD-L1 expression, which is induced by various cytokines… read more here.

Keywords: expression; none; human iapp; hiapp ... See more keywords