Biosynthesis and Structure-Activity Relationship Studies of Okaramines That Target Insect Glutamate-Gated Chloride Channels.
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DOI: 10.1021/acschembio.7b00878
Abstract: Prenylated indole alkaloid okaramines selectively target insect glutamate-gated chloride channels (GluCls). Because of their highly complex structures, including azocine and azetidine rings, total synthesis of okaramine A or B has not been achieved, preventing evaluation… read more here.
Keywords: target insect; glutamate gated; structure activity; insect glutamate ... See more keywords