Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome
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DOI: 10.1128/spectrum.00147-23
Abstract: The disease African trypanosomiasis imposes a severe human and economic burden for communities in sub-Saharan Africa. The parasite that causes the disease is transmitted to the bloodstream of a human or ungulate via the tsetse… read more here.
Keywords: bloodstream; stage parasites; bromodomain; bromodomain proteins ... See more keywords