Oxetane Monomers Based On the Powerful Explosive LLM-116: Improved Performance, Insensitivity, and Thermostability.
Sign Up to like & getrecommendations! Published in 2022 at "ChemPlusChem"
DOI: 10.1002/cplu.202200049
Abstract: 3-Bromomethyl-3-hydroxymethyloxetane represents an inexpensive and versatile precursor for the synthesis of 3,3-disubstituted oxetane derivatives. In the present work, its synthesis was improved and energetic oxetanes based on the explosive LLM-116 (4-amino-3,5-dinitro-1H-pyrazole) prepared. Reaching detonation velocities… read more here.
Keywords: explosive llm; insensitivity; llm; llm 116 ... See more keywords
Reaction mechanism, insensitivity and mechanical property of PTFE–Mg–W composites with magnesium particles surface modification
Sign Up to like & getrecommendations! Published in 2017 at "Rare Metals"
DOI: 10.1007/s12598-017-0962-1
Abstract: This paper aims at enhancing impact insensitivity of polytetrafluoroethylene (PTFE)–Mg–W without sacrificing bulk of energy released in the reaction and optimizing mechanical properties of PTFE–Mg–W by magnesium surface treatment. The reaction energy results indicate that… read more here.
Keywords: ptfe; ptfe modified; energy; reaction ... See more keywords
A novel biallelic single base insertion in WNK1 in a Pakistani family with congenital insensitivity to pain
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Human Genetics"
DOI: 10.1038/s10038-020-0734-x
Abstract: Hereditary sensory and autonomic neuropathy type II (HSANII) is a rare, recessively inherited neurological condition frequently involving insensitivity to pain. The subtype, HSAN2A, results from mutations in the gene WNK1. We identified a consanguineous Pakistani… read more here.
Keywords: hsanii; insensitivity pain; pakistani family; insensitivity ... See more keywords
A cognitive pathway to punishment insensitivity
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221634120
Abstract: Significance Insensitivity to the adverse consequences of our actions drives problematic behaviors such as those observed in substance use disorders, conduct disorder, and antisocial personality disorder. Two pathways have been proposed for this insensitivity: a… read more here.
Keywords: pathway based; pathway punishment; insensitivity; pathway ... See more keywords
William D. Willis, Jr, MD, PhD Memorial Lecture: The evolutionary history of nerve growth factor and nociception
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000001889
Abstract: Rare pathological mutations in a small group of genes in humans can lead to pain insensitivity, and such cases have been instrumental in driving drug discovery programs for new analgesics. A less frequently trodden track… read more here.
Keywords: capsaicin; pain insensitivity; naked mole; biology ... See more keywords
Enhancement of Insensitivity for Pitot-Static Probe by Static-Pressure Orifices Optimization
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Instrumentation and Measurement"
DOI: 10.1109/tim.2022.3162267
Abstract: Range of insensitivity is a crucial characteristic for pitot-static probe, and it is defined as the range of aerodynamic angle where the measurement error does not exceed acceptable tolerance. This article proposes a static orifice… read more here.
Keywords: static probe; pitot static; insensitivity; pressure ... See more keywords
AB0045 Il-17 induced glucocorticoid insensitivity might be dependent on the reduced 11beta-hsd1 enzyme activity
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.2681
Abstract: Background It has been demonstrated that IL-17A is able to induce GC insensitivity. Although several studies have reported the role of IL-17 in GC insensitivity the mechanism underlying remains still largely unclear. Objectives To understand… read more here.
Keywords: insensitivity; hsd1 enzyme; enzyme activity;
Development and Evaluation of a Nomogram for INCS Insensitivity in Chinese Adults with Allergic Rhinitis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Clinical Practice"
DOI: 10.1155/2023/3027092
Abstract: Objective The objective of this study was to design and validate a nomogram of intranasal corticosteroid (INCS) insensitivity for adult patients with allergic rhinitis (AR). Methods Training and validation datasets comprised randomly divided groups of… read more here.
Keywords: evaluation nomogram; insensitivity; development evaluation; incs insensitivity ... See more keywords
Whole-exome sequencing gives additional benefits compared to candidate gene sequencing in the molecular diagnosis of children with growth hormone or IGF-1 insensitivity.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of endocrinology"
DOI: 10.1530/eje-17-0453
Abstract: BACKGROUND GH insensitivity (GHI) is characterised by short stature, IGF-1 deficiency and normal/elevated serum GH. IGF-1 insensitivity results in pre- and post-natal growth failure with normal/high IGF-1 levels. The prevalence of genetic defects is unknown.… read more here.
Keywords: diagnosis; whole exome; igf insensitivity; candidate gene ... See more keywords
Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.770305
Abstract: HAS2 is a member of the gene family encoding the hyaluronan synthase 2, which can generate high-molecular-weight hyaluronan (HMW-HA). Our previous study identified HAS2 as a candidate gene for increased susceptibility to adult asthma. However,… read more here.
Keywords: has2; insensitivity; mice; airway remodeling ... See more keywords
Glucocorticoid Insensitivity in Asthma: The Unique Role for Airway Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23168966
Abstract: Although most patients with asthma symptoms are well controlled by inhaled glucocorticoids (GCs), a subgroup of patients suffering from severe asthma respond poorly to GC therapy. Such GC insensitivity (GCI) represents a profound challenge in… read more here.
Keywords: role; insensitivity; asthma; asm cells ... See more keywords