Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2357
Abstract: O-GlcNAc hydrolase (OGA) catalyzes removal of βα-linked N-acetyl-D-glucosamine from serine and threonine residues. We report crystal structures of Homo sapiens OGA catalytic domain in apo and inhibited states, revealing a flexible dimer that displays three… read more here.
Keywords: crystal structure; activity inhibition; inhibition crystal; structure human ... See more keywords
Insights into the activity control of the kallikrein-related peptidase 6: small-molecule modulators and allosterism
Sign Up to like & getrecommendations! Published in 2018 at "Biological Chemistry"
DOI: 10.1515/hsz-2017-0336
Abstract: Abstract The activity of kallikrein-related peptidase 6 (KLK6) is deregulated in various diseases such as cancer and neurodegenerative diseases. KLK6 is thus considered as an attractive therapeutical target. In this short report, we depict some… read more here.
Keywords: related peptidase; activity; kallikrein related; insights activity ... See more keywords