Insights into allosteric control of microtubule dynamics from a buried β‐tubulin mutation that causes faster growth and slower shrinkage
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3842
Abstract: αβ‐tubulin subunits cycle through a series of different conformations in the polymer lattice during microtubule growing and shrinking. How these allosteric responses to different tubulin:tubulin contacts contribute to microtubule dynamics, and whether the contributions are… read more here.
Keywords: microtubule; allosteric control; microtubule dynamics; tubulin ... See more keywords
Insights into Allosteric Mechanisms of the Lung-Enriched p53 Mutants V157F and R158L
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231710100
Abstract: Lung cancer is a leading fatal malignancy in humans. p53 mutants exhibit not only loss of tumor suppressor capability but also oncogenic gain-of-function, contributing to lung cancer initiation, progression and therapeutic resistance. Research shows that… read more here.
Keywords: insights allosteric; p53 mutants; lung; v157f r158l ... See more keywords