Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00078
Abstract: In the search of new antiplasmodial agents, a multitargeted approach was used in the synthesis of triazolopyrimidine- and 4-aminoquinolines-based hybrids. In vitro antiplasmodial evaluation on chloroquine-sensitive (3D7) and -resistant (W2) P. falciparum strains identified triazolopyrimidine-4-aminoquinoline… read more here.
Keywords: insights aminoquinoline; anti plasmodial; plasmodial activities; activities mechanistic ... See more keywords
Electronic insights into aminoquinoline-based PNHN ligands: protonation state dictates geometry while coordination environment dictates N-H acidity and bond strength.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt01556k
Abstract: A variety of transition metal complexes bearing aminoquinoline PNHH'-R ligands R = Ph (L1H), Cy (L2H) and their amido analogues are reported for rhodium(I) ([Rh(L1H)(PPh3)]+1 and Rh(L1)(PPh3) 2), cobalt(II) (Co(L2)(Cl) 3), and iron(II) ([Fe(L1H)2]2+5, Fe(L1)26,… read more here.
Keywords: insights aminoquinoline; based pnhn; geometry; electronic insights ... See more keywords