Structural insights into the assembly and activation of the IL‐27 signaling complex
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DOI: 10.15252/embr.202255450
Abstract: Interleukin 27 (IL‐27) is a heterodimeric cytokine that elicits potent immunosuppressive responses. Comprised of EBI3 and p28 subunits, IL‐27 binds GP130 and IL‐27Rα receptor chains to activate the JAK/STAT signaling cascade. However, how these receptors… read more here.
Keywords: cytokine; structural insights; assembly activation; signaling complex ... See more keywords