Mechanistic insights into ER-associated protein degradation.
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DOI: 10.1016/j.ceb.2018.04.004
Abstract: Misfolded proteins of the endoplasmic reticulum (ER) are discarded by a conserved process, called ER-associated protein degradation (ERAD). ERAD substrates are retro-translocated into the cytosol, polyubiquitinated, extracted from the ER membrane, and ultimately degraded by… read more here.
Keywords: associated protein; insights associated; erad; protein degradation ... See more keywords