Structural insights into constitutive activity of 5-HT6 receptor.
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DOI: 10.1073/pnas.2209917120
Abstract: While most therapeutic research on G-protein-coupled receptors (GPCRs) focuses on receptor activation by (endogenous) agonists, significant therapeutic potential exists through agonist-independent intrinsic constitutive activity that can occur in various physiological and pathophysiological settings. For example,… read more here.
Keywords: insights constitutive; structural insights; constitutive activity; ht6r ... See more keywords