Insights into Design of p97-targeting Small Molecules from Structural Studies on p97 Functional Mechanism.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/0929867326666191004162411
Abstract: p97, also known as valosin-containing protein or CDC48, is a member of the AAA+ protein family that is highly conserved in eukaryotes. It binds to various cofactors in the body to perform its protein-unfolding function… read more here.
Keywords: insights design; small molecules; mechanism; design p97 ... See more keywords
Insights for the design of protein lysine methyltransferase G9a inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0396
Abstract: The epigenetic control of gene expression could be affected by addition and/or removal of post-translational modifications such as phosphorylation, acetylation and methylation of histone proteins, as well as methylation of DNA (5-methylation on cytosines). Misregulation… read more here.
Keywords: insights design; design protein; g9a inhibitors; protein lysine ... See more keywords