Mechanistic Insights into the Ligand-Induced Unfolding of an RNA G-Quadruplex.
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DOI: 10.1021/jacs.1c11248
Abstract: The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand that can stabilize different topologies via multiple binding modes. However, TMPyP4 can have both a stabilizing and destabilizing effect on RNA G4 structures.… read more here.
Keywords: ligand induced; induced unfolding; rna; ligand ... See more keywords