Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
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DOI: 10.1038/s41589-020-0544-7
Abstract: Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the assistance of the substrate-binding 5-LOX-activating protein at the nuclear membrane.… read more here.
Keywords: akba; insights lipoxygenase; inhibition; structural mechanistic ... See more keywords