Molecular insights into the mechanism of nonrecurrent F8 structural variants: Full breakpoint characterization and bioinformatics of DNA elements implicated in the upmost severe phenotype in hemophilia A
Sign Up to like & getrecommendations! Published in 2020 at "Human Mutation"
DOI: 10.1002/humu.23977
Abstract: Hemophilia A (HA) provides excellent models to analyze genotype–phenotype relationships and mutational mechanisms. NhF8ld's breakpoints were characterized using case‐specific DNA‐tags, direct‐ or inverse‐polymerase chain reaction amplification, and Sanger sequencing. DNA‐break's stimulators (n = 46), interspersed repeats, non‐B‐DNA,… read more here.
Keywords: phenotype; breakpoint; severe phenotype; molecular insights ... See more keywords
New insights into the mechanism of photodegradation of chitosan.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.117715
Abstract: Chitosan films were subjected to accelerated artificial weathering at λ>300 nm and 60 °C in the presence of O2. The resulting variations in the chemical structure were characterized by IR spectroscopy and UV-vis spectroscopy, and… read more here.
Keywords: mechanism; mechanism photodegradation; photodegradation chitosan; spectroscopy ... See more keywords
Novel insights into the mechanism of electron transfer in mitochondrial cytochrome c
Sign Up to like & getrecommendations! Published in 2022 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2021.214233
Abstract: Abstract The supramolecular arrangement of respiratory complexes into supercomplexes is widely accepted. The common feature observed in the supercomplex architecture from organisms of diverse phylogenetic origin is the reduction of the distance between cytochrome bc1… read more here.
Keywords: electron transfer; cytochrome; novel insights; electron ... See more keywords
Some insights into the mechanism of photoluminescence of As-S-based films synthesized by PECVD
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Non-Crystalline Solids"
DOI: 10.1016/j.jnoncrysol.2019.03.015
Abstract: Abstract Chalcogenide arsenic sulphide thin films were obtained by reacting arsenic and sulfur vapors in a low-temperature plasma discharge. Photoluminescence (PL) of As-S films with compositions As34S66 and As53S47 is studied in detail. An increase… read more here.
Keywords: photoluminescence based; films synthesized; insights mechanism; based films ... See more keywords
Insights into Mechanism of Hypochlorite-induced Functionalization of Polymers towards Separating BFRs-contained Components from Microplastics.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c09586
Abstract: Surface functionalization of polymers is significant to an emerging flotation technique for separation of microplastics towards the recycling of plastic wastes. In this study, the hypochlorite-induced functionalization of polymers, including ABS, PMMA, PS, and PVC… read more here.
Keywords: hypochlorite induced; induced functionalization; functionalization; insights mechanism ... See more keywords
Insights into the Mechanism of Anodic N-N Bond Formation by Dehydrogenative Coupling.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b07488
Abstract: The electrochemical synthesis of pyrazolidine-3,5-diones and benzoxazoles by N-N bond formation and C,O linkage, respectively, represents an easy access to medicinally relevant structures. Electrochemistry as a key technology ensures a safe and sustainable approach. We… read more here.
Keywords: mechanism anodic; insights mechanism; bond formation; formation ... See more keywords
Insights into the mechanism of coreactant electrochemiluminescence facilitating enhanced bioanalytical performance
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16476-2
Abstract: Electrochemiluminescence (ECL) is a powerful transduction technique with a leading role in the biosensing field due to its high sensitivity and low background signal. Although the intrinsic analytical strength of ECL depends critically on the… read more here.
Keywords: electrochemiluminescence; generation; mechanism coreactant; ecl ... See more keywords
Experimental and computational insights into the mechanism of FLP mediated selective C–F bond activation
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc05632a
Abstract: Frustrated Lewis pairs (FLP) comprising of B(C6F5)3 (BCF) and 2,4,6-triphenylpyridine (TPPy), P(o-Tol)3 or tetrahydrothiophene (THT) have been shown to mediate selective C–F activation in both geminal and chemically equivalent distal C–F sites. In comparison to… read more here.
Keywords: experimental computational; mechanism flp; activation; insights mechanism ... See more keywords
Tirbanibulin for Actinic Keratosis: Insights into the Mechanism of Action
Sign Up to like & getrecommendations! Published in 2022 at "Clinical, Cosmetic and Investigational Dermatology"
DOI: 10.2147/ccid.s374122
Abstract: Abstract Actinic keratosis (AK) is a common pre-neoplastic skin lesion constituted by uncontrolled proliferation of atypical keratinocytes that may evolve to squamous cell carcinoma. With global prevalence increasing, AK is expected to be the most… read more here.
Keywords: tirbanibulin actinic; tirbanibulin; actinic keratosis; keratosis insights ... See more keywords
Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21165859
Abstract: Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs). Apart from being critically involved in fibrinolysis and wound healing, emerging evidence indicates that PAI-1 plays an… read more here.
Keywords: pai; nanobody; structural insights; mechanism nanobody ... See more keywords
Insights into the Mechanism of Human Deiodinase 1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105361
Abstract: The three isoenzymes of iodothyronine deiodinases (DIO1-3) are membrane-anchored homo-dimeric selenoproteins which share the thioredoxin-fold structure. Several questions regarding their catalytic mechanisms still remain open. Here, we addressed the roles of several cysteines which are… read more here.
Keywords: human deiodinase; mechanism human; insights mechanism; dio1 ... See more keywords