Modeling Hypertrophic Cardiomyopathy: Mechanistic Insights and Pharmacological Intervention.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2019.06.005
Abstract: Hypertrophic cardiomyopathy (HCM) is a prevalent and complex cardiovascular disease where cardiac dysfunction often associates with mutations in sarcomeric genes. Various models based on tissue explants, isolated cardiomyocytes, skinned myofibrils, and purified actin/myosin preparations have… read more here.
Keywords: cardiomyopathy mechanistic; modeling hypertrophic; hypertrophic cardiomyopathy; pharmacological intervention ... See more keywords
Insights into Pharmacological Potential of Apigenin through various Pathways on a Nanoplatform in Multitude of Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical design"
DOI: 10.2174/1381612829666230529164321
Abstract: Apigenin is a natural polyphenolic compound widely distributed as a glycoside in fruits and vegetables. Apigenin belongs to BCS class II with low solubility, which leads to poor absorption and bioavailability. It is mostly absorbed… read more here.
Keywords: pharmacological potential; various pathways; apigenin various; insights pharmacological ... See more keywords
Insights into the Pharmacological Effects of Flavonoids: The Systematic Review of Computer Modeling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116023
Abstract: Computer modeling is a method that is widely used in scientific investigations to predict the biological activity, toxicity, pharmacokinetics, and synthesis strategy of compounds based on the structure of the molecule. This work is a… read more here.
Keywords: computer modeling; systematic review; insights pharmacological; computer ... See more keywords
Mechanistic Insights into the Pharmacological Significance of Silymarin
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165327
Abstract: Medicinal plants are considered the reservoir of diverse therapeutic agents and have been traditionally employed worldwide to heal various ailments for several decades. Silymarin is a plant-derived mixture of polyphenolic flavonoids originating from the fruits… read more here.
Keywords: silymarin; insights pharmacological; significance silymarin; pharmacological significance ... See more keywords