Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques
Sign Up to like & getrecommendations! Published in 2024 at "Amino Acids"
DOI: 10.1007/s00726-023-03367-1
Abstract: Alzheimer’s disease (AD) is the most prevalent type of dementia caused by the accumulation of amyloid beta (Aβ) peptides. The extracellular deposition of Aβ peptides in human AD brain causes neuronal death. Therefore, it has… read more here.
Keywords: binding; active site; structural insights; potential binding ... See more keywords
Insights into the Potential Role of Mercury in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01274-3
Abstract: Mercury (Hg), which is a non-essential element, is considered a highly toxic pollutant for biological systems even when present at trace levels. Elevated Hg exposure with the growing release of atmospheric pollutant Hg and rising… read more here.
Keywords: alzheimer disease; insights potential; exposure; potential role ... See more keywords
Molecular and physiological insights into the potential efficacy of CO2-augmented postharvest cold treatments for false codling moth
Sign Up to like & getrecommendations! Published in 2017 at "Postharvest Biology and Technology"
DOI: 10.1016/j.postharvbio.2017.06.002
Abstract: Abstract Cold sterilisation may be supplemented with elevated CO 2 (hypercapnia) to increase pest mortality however, in some cases, such treatment combinations have generated unexpected high levels of pest survival. Consequently, determining the mechanistic basis… read more here.
Keywords: insights potential; false codling; codling moth; larval survival ... See more keywords
Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000335
Abstract: Ample evidence has pointed to a close link between oxidative stress, mitochondrial dysfunction, and depression. Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a master regulator of cellular redox homeostasis and affects mitochondrial function. Nrf2 holds promise… read more here.
Keywords: potential antidepressant; antidepressant mechanisms; nrf2 pathway; insights potential ... See more keywords
Multiomics genetic insights into potential molecular targets for intracranial aneurysm
Sign Up to like & getrecommendations! Published in 2025 at "Stroke and Vascular Neurology"
DOI: 10.1136/svn-2025-004175
Abstract: Background This study aimed to identify multiomics therapeutic targets for aneurysmal subarachnoid haemorrhage (aSAH) and unruptured intracranial aneurysm (uIA) using Mendelian randomisation (MR), summary-data-based MR (SMR) and postanalysis methods. Methods Significant genetic variables were extracted… read more here.
Keywords: analysis; genetic insights; protein; insights potential ... See more keywords
Mechanistic insights and potential therapeutic targets for NUP98-rearranged hematologic malignancies.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020007093
Abstract: Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes. While wildtype full length NUP98 is a member of the nuclear pore complex, the chromosomal… read more here.
Keywords: insights potential; hematologic malignancies; fusion; nup98 fusion ... See more keywords
Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications
Sign Up to like & getrecommendations! Published in 2022 at "Aging and Disease"
DOI: 10.14336/ad.2021.0823
Abstract: Diabetic Encephalopathy (DE) is one of the complications of diabetes mellitus (DM) in the central nervous system. Up to now, the mechanisms of DE are not fully discussed by the field. Autophagy is an intracellular… read more here.
Keywords: insights potential; potential therapeutic; diabetic encephalopathy; mechanistic insights ... See more keywords
Human and mouse angiogenins: Emerging insights and potential opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1022945
Abstract: Angiogenin, a well-known angiogenic factor, is crucial to the angiogenesis in gastrointestinal tumors. Human angiogenin has only one gene, whereas the murine angiogenin family has extended to incorporate six genes. Evolutionary studies have suggested functional… read more here.
Keywords: human mouse; insights potential; angiogenins emerging; emerging insights ... See more keywords
Novel Insights in the Potential of Halogenated Polyketide–Peptide Molecules as Lead Compounds in Cancer Drug Discovery
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076208
Abstract: In this interdisciplinary study, we selected two compounds, namely, smenamide A, a peptide–polyketide, and smenolactone D, a polyketide, as models because they are representative of two different classes of molecules isolated from the marine sponge… read more here.
Keywords: halogenated polyketide; polyketide peptide; insights potential; potential halogenated ... See more keywords
Insights on Potential Formation Damage Mechanisms Associated with the Use of Gel Breakers in Hydraulic Fracturing
Sign Up to like & getrecommendations! Published in 2020 at "Polymers"
DOI: 10.3390/polym12112722
Abstract: Hydraulic fracturing using water-soluble polymers has been extensively used to enhance the productivity of oil and gas wells. However, the production enhancement can be significantly impaired due to polymer residue generated within the proppant pack… read more here.
Keywords: insights potential; potential formation; formation damage; gel breakers ... See more keywords