Insights into substrate recognition and export tunnel preferences in the efflux transporter AcrB
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DOI: 10.1002/pro.5252
Abstract: In Escherichia coli AcrB is a major multidrug exporter, which confers the bacterium resistance to many antibiotics with diverse structural and chemical proprieties. Studies have identified three possible tunnels (or channels) within AcrB that different… read more here.
Keywords: tunnel preferences; insights substrate; export tunnel; export ... See more keywords
Structural Insights into Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00305
Abstract: Salinomycin with antibacterial and anticoccidial activities is a commercial polyether polyketide widely used in animal husbandry as a food additive. Malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA) and ethylmalonyl-CoA (EMCoA) are used as extension units in its biosynthesis.… read more here.
Keywords: structural insights; polyketide synthase; specificity acyltransferases; insights substrate ... See more keywords
Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92480-w
Abstract: Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift of SULT structure caused by PAPS binding… read more here.
Keywords: insights substrate; paps bound; molecular dynamics; excited normal ... See more keywords
Structural Insights into the Substrate Transport Mechanisms in GTR Transporters through Ensemble Docking
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031595
Abstract: Glucosinolate transporters (GTRs) are part of the nitrate/peptide transporter (NPF) family, members of which also transport specialized secondary metabolites as substrates. Glucosinolates are defense compounds derived from amino acids. We selected 4-methylthiobutyl (4MTB) and indol-3-ylmethyl… read more here.
Keywords: structural insights; insights substrate; substrate transport; transport ... See more keywords
Structural Insights into Substrate Binding and Antibiotic Inhibition of Enterobacterial Penicillin-Binding Protein 6
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12071022
Abstract: Shigella sonnei remains the second most common cause of shigellosis in young children and is now increasingly dominant across developing countries. The global emergence of drug resistance has become a main burden in the treatment… read more here.
Keywords: penicillin; structural insights; binding antibiotic; substrate binding ... See more keywords