Structural Insights into Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00305
Abstract: Salinomycin with antibacterial and anticoccidial activities is a commercial polyether polyketide widely used in animal husbandry as a food additive. Malonyl-CoA (MCoA), methylmalonyl-CoA (MMCoA) and ethylmalonyl-CoA (EMCoA) are used as extension units in its biosynthesis.… read more here.
Keywords: structural insights; polyketide synthase; specificity acyltransferases; insights substrate ... See more keywords
Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations
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DOI: 10.1038/s41598-021-92480-w
Abstract: Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift of SULT structure caused by PAPS binding… read more here.
Keywords: insights substrate; paps bound; molecular dynamics; excited normal ... See more keywords
Structural Insights into the Substrate Transport Mechanisms in GTR Transporters through Ensemble Docking
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DOI: 10.3390/ijms23031595
Abstract: Glucosinolate transporters (GTRs) are part of the nitrate/peptide transporter (NPF) family, members of which also transport specialized secondary metabolites as substrates. Glucosinolates are defense compounds derived from amino acids. We selected 4-methylthiobutyl (4MTB) and indol-3-ylmethyl… read more here.
Keywords: structural insights; insights substrate; substrate transport; transport ... See more keywords
Structural Insights into Substrate Binding and Antibiotic Inhibition of Enterobacterial Penicillin-Binding Protein 6
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DOI: 10.3390/life12071022
Abstract: Shigella sonnei remains the second most common cause of shigellosis in young children and is now increasingly dominant across developing countries. The global emergence of drug resistance has become a main burden in the treatment… read more here.
Keywords: penicillin; structural insights; binding antibiotic; substrate binding ... See more keywords