New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency.
Sign Up to like & getrecommendations! Published in 2020 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2020.08.005
Abstract: OBJECTIVE To characterize circulating insulin-like factor 3 (INSL3) in different stages of ovarian insufficiency and its role in the evaluation of premature ovarian insufficiency (POI). DESIGN Retrospective cohort study. SETTING University-based center for reproductive medicine.… read more here.
Keywords: insl3; like factor; insulin like; ovarian insufficiency ... See more keywords
Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates.
Sign Up to like & getrecommendations! Published in 2020 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2020.113583
Abstract: Although the insulin-like peptide hormone INSL3 and its cognate receptor RXFP2 (relaxin-family peptide receptor 2) have existed throughout chordate evolution, their physiological diversification appears to be linked closely with mammalian emergence and radiation. In contrast,… read more here.
Keywords: evolution; insl3 rxfp2; insl3; physiology ... See more keywords
Effects of Osteocalcin on Synthesis of Testosterone and INSL3 during Adult Leydig Cell Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Endocrinology"
DOI: 10.1155/2019/1041760
Abstract: Proliferation and differentiation of adult Leydig cells are mainly completed in puberty. In many studies, apart from normal postnatal development process, it is widely indicated that, through administrating EDS, Leydig cell population is eliminated and… read more here.
Keywords: insl3; testosterone; adult leydig; leydig ... See more keywords
INSL3: a marker of Leydig cell function and testis-bone-skeletal muscle network.
Sign Up to like & getrecommendations! Published in 2020 at "Protein and peptide letters"
DOI: 10.2174/0929866527666200925105739
Abstract: This article reviews the role of INSL3 as biomarker of Leydig cell function and its systemic action in testis-boneskeletal muscle crosstalk in adult men. Insulin-like factor 3 (INSL3) is a peptide hormone secreted constitutively in… read more here.
Keywords: leydig cell; leydig; cell function; insl3 ... See more keywords
Protective Role of Testicular Hormone INSL3 From Atrophy and Weakness in Skeletal Muscle
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00562
Abstract: Androgens are primarily involved in muscle growth, whilst disease-driven muscle wasting is frequently associated with hypogonadism. The Leydig cells of the testes also produce the peptide-hormone Insulin-like peptide 3 (INSL3). INSL3 displays anabolic activity on… read more here.
Keywords: skeletal muscle; insl3; muscle; role testicular ... See more keywords
The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1016107
Abstract: Background Insulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number… read more here.
Keywords: insl3; hypogonadism; age related; emas cohort ... See more keywords
Expression and Role of INSL3 in the Fetal Testis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.868313
Abstract: Insulin-like peptide 3 (INSL3) is a small peptide hormone of the insulin-relaxin family which is produced and secreted by the fetal Leydig cells in the testes only. It appears to be undetectable in female fetuses.… read more here.
Keywords: testis; insl3 fetal; expression role; insl3 ... See more keywords